Beta-lipotropin is the major component of the plasma opioid response to surgical stress in humans |
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| Affiliation: | 1. Istitutes of Human Physiology, University of Modena, Via Campi 287, 41100 Modena, Italy;1. Department of Chemical Engineering, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria;2. Department of Chemical Engineering, College of Engineering and Technology, Landmark University, Omu-aran, Nigeria;3. Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, P. M. B. 5025, Awka, Nigeria;4. Department of Mechanical Engineering, Ladoke Akintola University of Technology, P. M. B. 4000, Ogbomosho, Nigeria;5. Department of Agricultural Engineering, Ladoke Akintola University of Technology, P. M. B. 4000, Ogbomosho, Nigeria;6. Department of Industrial Chemistry, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria;7. Energy, Sensors and Multifunctional Nanomaterials Research Group, Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, Johannesburg, South Africa;1. Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji’nan 250300, PR China;2. College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China;3. College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Lin’an 311300, PR China;4. Beijing Center for Disease Control and Prevention, Beijing 100013, PR China;1. Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, 133207, Haryana, India;2. Department of Biotechnology, Sri Guru Gobind Singh College Sector-26, Chandigarh, UT, 160019, India;3. Department of Bio& Nanotechnology, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, 125001, India;1. Institute of Medical Virology, Wenzhou Medical University, Wenzhou 325000, China;2. Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China;3. State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;1. Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77845, USA;2. Texas A&M Energy Institute, Texas A&M University, College Station, TX 77845, USA;3. Department of Petroleum Engineering, Texas A&M University, College station, TX 77845, USA |
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| Abstract: | There is growing experimental evidence that beta-endorphin immunoreactivity is raised by surgical stress in patients undergoing general anesthesia. As the assay methods employed to date did not allow to fully discriminate between beta-endorphin and its immediate precursor, beta-lipotropin, we have investigated in the present study plasma levels of these two peptides by separating them by chromatography on plasma extracts prior to radioimmunoassay in eighteen surgical patients under general anesthesia and eight under spinal anesthesia.Beta-lipotropin, but not beta-endorphin, plasma levels were found to be significantly elevated during surgery in the general anesthesia group, while no change was found in either peptide concentration in the spinal one. Cortisol plasma levels also increased significantly 90 minutes after the beginning of surgery, when they were positively correlated to beta-lipotropin ones. Although the sampling time we adopted may have prevented us from detecting an early peak of beta-endorphin during the first 30 minutes of surgery, the major component of the pituitary opioid response to surgical stress appears to be related to beta-lipotropin. This is in agreement with results of experimental work on various kinds of stress in animals and humans and seems to rule out a role for plasma beta-endorphin in post-operative analgesia. |
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