Molecular cloning of human plasma glutathione peroxidase gene and its expression in the kidney. |
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| Authors: | S Yoshimura H Suemizu Y Taniguchi K Watanabe Y Nomoto Y Katsuoka S Arimori T Moriuchi |
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| Institution: | Department of Cell Biology, Tokai University School of Medicine, Kanagawa, Japan. |
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| Abstract: | A genomic clone containing the human plasma glutathione peroxidase (GSH-Px) gene has been isolated using a rat plasma GSH-Px cDNA as a probe. The partial nucleotide sequence of the clone completely matched the sequence of the human plasma GSH-Px cDNA. The results of Southern blot hybridization indicate that the human plasma GSH-Px gene consists of at least 4 exons and 3 introns, and spans about 12 kb. RNA blot analysis demonstrated that the human plasma GSH-Px gene is expressed in the kidney. |
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