Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats |
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| Authors: | Satturwar P M Fulzele S V Joshi S B Dorle A K |
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| Institution: | Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur 440 010, India. |
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| Abstract: | Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and bilirubin in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. The protective effect was further supported by reversal of CCl4 induced histological changes. The results demonstrate significant hepatoprotective action of H. ghrita in CCl4 damaged rats. |
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