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Sequence-specific modification of DNA by 6-hydroxybenzo[a]pyrene |
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| Authors: | J Morita K Ueda S Kobayashi T Komano |
| Abstract: | 6-Hydroxybenzo[a]pyrene cleaved phi X174 supercoiled DNA to open circular DNA in the presence of heavy metal ions. It induced an alkali-labile modification in DNA via an oxygen-radical-mediated reaction; the most frequent alkali-labile sites were on the 3' side of the pyrimidine residues of the pyrimidine cluster. |
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