Chromosomal location of a major tRNA gene cluster of Xenopus laevis |
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| Authors: | Jennifer Fostel Sandya Narayanswami Barbara Hamkalo Stuart G. Clarkson Mary Lou Pardue |
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| Affiliation: | (1) Department of Biology, Massachusetts Institute of Technology, 02139 Cambridge, MA, USA;(2) Department of Molecular Biology and Biochemistry, University of California, 92717 Irvine, CA, USA;(3) Department of Microbiology, University of Geneva Medical School, CH-1205 Geneva, Switzerland |
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| Abstract: | In Xenopus laevis, genes encoding tRNAPhe, tRNATyr, tRNA1Met, tRNAAsn, tRNAAla, tRNALeu, and tRNALys are clustered within a 3.18-kb (kilobase) fragment of DNA. This fragment is tandemly repeated some 150 times in the haploid genome and its components are found outside the repeat only to a limited extent. The fragment hybridizes in situ to a single site very near the telomere on the long arm of one of the acrocentric chromosomes of the group comprising chromosomes 13–18. All the chromosomes of this group also hybridize with DNA coding for oocyte-specific 5S RNA. The tRNA gene cluster is slightly proximal to the cluster of 5S RNA genes.We respectfully dedicate this paper to Prof. H. Bauer on the occasion of his 80th birthday. |
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