富马酸比索洛尔对老年慢性心力衰竭患者血清胆红素、NT-proBNP及运动耐力的影响

摘要 目的：探究富马酸比索洛尔对老年慢性心力衰竭患者血清胆红素、N-末端B型利钠肽原（N-Terminal pro-brain natriuretic peptide，NT-proBNP）及运动耐力的影响。方法：选择我院于2017年1月~2020年1月收治的老年慢性心力衰竭患者80例，根据入院顺序经随机数字表法分成两组，对照组40例患者仅采用常规治疗方案进行治疗，研究组40例患者在常规治疗基础上联合富马酸比索洛尔进行治疗。对比两组患者治疗总有效率、左心室射血分数（left ventricular ejection fraction，LVEF）、心排量（cardiac output，CO）、每搏输出量（stroke volume，SV）、血清 NT-proBNP水平、6 min 步行测试距离、总胆红素、直接胆红素水平。结果：研究组的治疗总有效率90.00 %，显著高于对照组72.50 %（P＜0.05）； 治疗前，两组的LVEF、CO、SV水平对比无差异（P＞0.05）；治疗后，两组的LVEF、CO、SV水平均升高，且研究组更高（P＜0.05）；治疗前，两组的NT-proBNP水平及6 min 步行测试距离对比无显著性差异（P＞0.05）；治疗后，两组的NT-proBNP水平比治疗前均显著降低、6 min 步行测试距离比治疗前均显著升高，且研究组更优（P＜0.05）；治疗前，两组的总胆红素、直接胆红素水平对比无差异（P＞0.05）；治疗后，两组的总胆红素、直接胆红素水平均比治疗前显著降低，且研究组显著低于对照组（P＜0.05）。结论：在常规治疗基础上联合富马酸比索洛尔治疗老年慢性心力衰竭的临床效果显著，其可有效改善患者心功能及运动耐力，值得推荐至临床广泛应用。

Effects of Bisoprolol Fumarate on Serum Bilirubin, NT-proBNP and Exercise Tolerance in Elderly Patients with Chronic Heart Failure

ABSTRACT Objective: To investigate the effect of bisoprolol fumarate on serum bilirubin, NT-proBNP and exercise tolerance in elderly patients with chronic heart failure. Methods: A total of eighty elderly patients with chronic heart failure, who were admitted to Xinjiang Uygur Autonomous Region People''s Hospital from January 2017 to January 2020, were selected as the research subjects and were randomly divided into two groups according to the order of admission. The 40 patients in the control group were only treated with conventional treatment, and the 40 patients in the study group were treated with bisoprolol fumarate based on the conventional treatment. The total treatment efficiency, left ventricular ejection fraction (LVEF), cardiac output (CO), stroke volume (SV), serum NT-proBNP level, 6-minute walking test distance, total bilirubin, and direct bilirubin levels were compared between the two groups. Results: The total effective rate of treatment in the study group was 90.00 %, which was significantly higher than that in the control group (72.50%, P<0.05). Before treatment, there was no significant difference in LVEF, CO, and SV levels between the two groups of patients (P>0.05); after treatment, the LVEF, CO, and SV levels of the two groups of patients increased, and the study group was higher (P<0.05). Before treatment, there was no significant difference in NT-proBNP level and 6-minute walking test distance between the two groups of patients (P>0.05). After treatment, the NT-proBNP levels of the two groups of patients were significantly lower than before treatment, the 6-minute walking test distance was significantly higher than before treatment, and the study group was better (P<0.05). Before treatment, there was no significant difference in total bilirubin and direct bilirubin levels between the two groups of patients (P>0.05). After treatment, the levels of total bilirubin and direct bilirubin in the two groups were significantly lower than before treatment, and the study group was significantly lower than the control group (P<0.05). Conclusion: On the basis of conventional treatment, combined with bisoprolol fumarate in the treatment of elderly chronic heart failure has a significant effect, it can effectively improve the patient''s heart function and exercise endurance, which is worth recommending to clinical application.