Th17及相关细胞因子与酒精性肝硬化患者肝脏硬度值、肝功能及脂联素水平的相关性分析

摘要 目的：探讨Th17及相关细胞因子与酒精性肝硬化患者肝脏硬度值（LSM）、肝功能及脂联素（APN）水平的相关性分析。方法：以2018年1月~2020年1月本院收治的酒精性肝硬化患者72例作为酒精性肝硬化组，同期在本院进行体检的健康志愿者100例作为健康对照组。对比两组研究对象Th17、白介素-17（IL-17）、LSM、肝功能指标、APN水平的差异，采用Pearson检验评估酒精性肝硬化患者Th17及IL-17与病情相关指标的相关性。结果：酒精性肝硬化组患者的Th17细胞分布比例、IL-17水平、LSM均高于健康对照组（P<0.05）。外周血中谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（STB）的水平高于健康对照组，白蛋白（ALB）的水平低于健康对照组，血清中APN的水平低于健康对照组（P<0.05）。相关性分析发现，酒精性肝硬化患者Th17细胞分布比例及IL-17水平与LSM、ALT、AST、STB的水平呈正相关，与ALB、APN的水平呈负相关（P<0.05）。结论：酒精性肝硬化患者Th17及其细胞因子IL-17表达水平异常增高，可能在反映病情相关指标异常变化程度方面具有积极作用。

Correlation Analysis of Th17 and Related Cytokines with Liver Stiffness Measurement, Liver Function and Adiponectin Levels in Alcoholic Cirrhosis Patients

ABSTRACT Objective: To investigate the correlation between Th17 and related cytokines with liver stiffness measurement (LSM), liver function and adiponectin (APN) levels in alcoholic cirrhosis patients. Methods: 72 cases of alcoholic cirrhosis patients admitted to our hospital from January 2018 to January 2020 were treated as alcoholic cirrhosis group, 100 healthy volunteers who underwent physical examination in our hospital during the same period were treated as healthy control group. Differences of Th17, interleukin-17 (IL-17), LSM, liver function indicators, APN levels between two groups were compared. Pearson test was used to evaluate the correlation between Th17 and IL-17 with disease related indicators in alcoholic cirrhosis patients. Results: Distribution ratio of Th17, IL-17 levels, LSM in alcoholic cirrhosis group were higher than those in healthy control group (P<0.05). The levels of alanine aminotransferase (ALT), aspartate transaminase(AST) and serum total bilirubin(STB) in peripheral blood in alcoholic cirrhosis group were higher than those in healthy control group, albumin(ALB) was lower than that in healthy control group, the level of APN in serum was lower than that in healthy control group(P<0.05). The correlation analysis showed that the Th17 distribution ratio and IL-17 level in alcoholic cirrhosis patients were positively correlated with the levels of LSM, ALT, AST and STB, and negatively correlated with the levels of ALB and APN (P<0.05). Conclusion: The expression levels of Th17 and IL-17 increase abnormally in alcoholic cirrhosis patients, it may be a good indicator that reflects the degree of abnormal changes in disease.