曲普瑞林联合小剂量生长激素物治疗女童CPP疗效及对骨龄的影响

摘要 目的：探讨曲普瑞林联合小剂量生长激素物治疗女童CPP疗效及对骨龄影响。方法：选取2017年1月至2020年1月我院收治的200例CPP女童，随机将其分为两组，对照组100例，给予常规治疗，研究组100例，给予曲普瑞林联合小剂量生长激素治疗。观察两组患者的临床疗效、治疗前后血清性激素水平、子宫容积、卵巢容积变化情况以及生长发育指标变化。结果：治疗后，研究组总有效率为98 %；显著高于对照组总有效率（80 %，P＜0.05）。两组FSH、LH、E₂水平、子宫容积、卵巢容积均降低，骨龄、身高、PAH均显著升高，且研究组上述指标明显优于对照组（P<0.05）。结论：曲普瑞林联合小剂量生长激素物治疗女童CPP疗效显著，能很好的改善患者血清性激素水平、子宫容积、卵巢容积，对生长发育指标具有积极的意义，值得临床推广和应用。

Efficacy of Triptorelin Combined with Low-dose Growth Hormone on Central Precocious Puberty in Girls

ABSTRACT Objective: To investigate the efficacy of triptorelin combined with low-dose growth hormone in the treatment of girls with central precocious puberty (CPP) and its effect on bone age. Methods: A total of 200 girls with CPP,who were admitted to People''s Hospital of Shaanxi Province from January 2017 to January 2020, were chosen as research subjects and were randomly divided into control group(n=100) and study group(n=100).The control group was given conventional treatment, and the study group was given triptorelin combined with low-dose growth hormone therapy. The clinical efficacy of, serum sex hormone levels before and after treatment, changes in uterine volume, ovarian volume, and changes in growth and development indicators of the two groups of patients were observed. Results: After treatment, the total effective rate(98 %) in the study group was significantly higher than that(80 %) in the control group (P<0.05). The levels of FSH, LH, E₂, uterine volume, and ovarian volume of the two groups were reduced, and bone age, height, and PAH were significantly increased. The above indicators of the study group were significantly better than those of the control group (P<0.05). Conclusion: Triptorelin combined with low-dose growth hormone has a significant effect in the treatment of girls with CPP. It can improve the serum sex hormone levels, uterine volume, and ovarian volume of the girls with CPP . It has positive significance for growth and development indicators and is worthy of clinical promotion and application.