药火针联合补阳还五汤加减治疗糖尿病痹症疗效及神经因子影响

摘要 目的：探讨药火针联合补阳还五汤加减治疗糖尿病痹症疗效及神经因子影响。方法：选取我院2017年1月~2020年4月所收治的80例糖尿病痹症患者，随机分为两组，每组40例，两组均给予常规西医治疗，研究组在此基础上应用药火针联合补阳还五汤加减治疗，对照组不予以其他特殊治疗，对比不同治疗方法治疗糖尿病痹症疗效及神经因子影响。结果：研究组患者治疗后正中神经和腓总神经的运动神经传导速度（Motor Nerve Conduction Velocity，MNCV）和感觉神经传导速（Sensory Nerve Conduction Velocity，SNCV）均明显高于对照组（P＜0.05）；研究组患者治疗后人脑源性神经营养因子（brain-derived neuro-trophic factor，BDNF）、人胰岛素样生长因子1（insulin-like growth factor 1，IGF-1）、人神经生长因子（nerve growth factor，NGF）明显高于对照组，人髓磷脂碱性蛋白（myelinBasle Protein，MBP）明显低于对照组（P＜0.05）；研究组患者的治疗有效率92.5 %明显高于对照组75 %（P＜0.05）。结论：药火针联合补阳还五汤加减治疗糖尿病痹症，可有效改善糖尿病痹症的临床症状，改善病变神经传导速度及神经因子，对改善神经功能具有显著的临床效果，可提升治疗有效率，值得临床上推广应用。

Therapeutic Effect and Influence of Nerve Factors on Diabetic Arthralgia Treated by Herbal Fire Acupuncture Dombined with Buyang Huanwu Decoction

ABSTRACT Objective: To explore the curative effect and the influence of nerve factor of the treatment of diabetic arthralgia by the combination of medicine fire acupuncture and Buyang Huanwu Decoction. Methods: 80 patients with diabetic arthralgia admitted to our hospital from January 2017 to April 2020 were randomly divided into study group and control group, 40 patients in each group. Two groups were treated with conventional western medicine. On this basis, the patients in the study group were treated with traditional Chinese medicine and fire acupuncture combined with Buyang Huanwu Decoction. The control group was not given other special treatment, and different treatment methods were compared to treat diabetic arthralgia Effect and the influence of nerve factors. Results: The MNCV and SNCV of median nerve and common peroneal nerve in the study group were significantly higher than those in the control group (P<0.05). The BDNF, IGF-1 and NGF in the study group were significantly higher than those in the control group(P<0.05), MBP was significantly lower than the control group(P<0.05). Conclusion: The treatment of diabetic arthralgia with herbal fire acupuncture combined with Buyang Huanwu Decoction can effectively improve the clinical symptoms of diabetic arthralgia, improve the pathological nerve conduction velocity and nerve factors, have significant clinical effect on improving the nerve function, can improve the treatment efficiency, and is worthy of clinical application.