1. Department of Biology, CB 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;2. Department of Cellular and Molecular Medicine, Arizona Cancer Center, Room 3951, University of Arizona, 1515 N. Campbell Avenue, Tucson, AZ 85724, USA
Abstract:
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Highlights? The Plk4 cryptic polo box is a structurally unique, tandem polo box array: PB1-PB2 ? Full length Plk4 comprises three polo box domains, a unique polo kinase architecture ? The Plk4 PB1-PB2 cassette is required for Asterless binding and centriole targeting ? The Plk4 PB1-PB2 homodimer potentiates Plk4 degradation
