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Structure of NPP1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification

Authors:	Silvia Jansen Anastassis Perrakis Chris Ulens Claudia Winkler Maria Andries Robbie P Joosten Maarten Van Acker Frank P Luyten Wouter H Moolenaar Mathieu Bollen

Institution:	1. Laboratory of Biosignaling and Therapeutics, Department of Cellular and Molecular Medicine, University of Leuven, 3000 Leuven, Belgium;2. Laboratory of Structural Neurobiology, Department of Cellular and Molecular Medicine, University of Leuven, 3000 Leuven, Belgium;3. Laboratory for Skeletal Development and Joint Disorders, University of Leuven, 3000 Leuven, Belgium;4. Division of Biochemistry, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands;5. Division of Cell Biology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands

Abstract:	Download : Download high-res image (333KB) Download : Download full-size image Highlights? We determine the crystal structure of mouse NPP1 ? We elucidate the mechanism of NPP1 dimer formation and secretion ? The structure explains the dramatic functional differences between NPP1 and NPP2 ? The structure allows defining the impact of pathogenic mutations in human NPP1

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