早发冠心病患者血清锌a2糖蛋白、单核细胞趋化蛋白-1水平与血脂的关系及其影响因素分析

摘要 目的：分析早发冠心病（PCAD）患者血清锌a2糖蛋白（ZAG）、单核细胞趋化蛋白-1（MCP-1）水平与血脂的关系及其影响因素。方法：收集2017年1月-2019年12月在我院经冠状动脉造影确诊的冠心病患者184例，其中PCAD 患者86例（PCAD组），非PCAD患者98例（NPCAD组），再选取同期男性<55岁，女性<65岁健康体检者86例作为对照组。收集所有研究对象的基线资料并检测空腹血糖(FBG) 、总胆固醇(TC) 、低密度脂蛋白(LDL) 、甘油三酯(TG) 、高密度脂蛋白(HDL)、血清ZAG、MCP-1水平，采用Pearson相关性分析ZAG、MCP-1与血脂相关性。多因素Logistic回归分析PCAD的影响因素。结果：PCAD组、NPCAD组糖尿病史、高血压病史、冠心病家族史比例、体质量指数(BMI)、FPG、TG、MCP-1高于对照组，HDL、ZAG水平低于对照组（P＜0.05），PCAD组年龄、HDL、ZAG水平低于NPCAD组，冠心病家族史、吸烟史比例高于NPCAD组（P＜0.05）。Pearson相关性分析结果表明，PCAD患者ZAG与HDL呈正相关，MCP-1与HDL呈负相关（P＜0.05）；多因素Logistic回归分析显示，高血压、吸烟史、冠心病家族史、HDL、TG、ZAG、MCP-1是PCAD的独立危险因素。结论：PCAD患者MCP-1水平升高、ZAG、HDL水平降低，MCP-1、ZAG与HDL密切相关，且是PCAD的独立危险因素。

Relationship between Serum Zinc a2 Glycoprotein and Monocyte Chemotactic Protein-1 Levels and Blood Lipids in Patients with Premature Coronary Artery Disease and Analysis of Influencing Factors

ABSTRACT Objective: To analyze the relationship between serum zinc a2 glycoprotein (ZAG), monocyte chemotactic protein-1 (MCP-1) levels and blood lipids and their influencing factors in patients with premature coronary artery disease (PCAD). Methods: 84 patients with coronary heart disease diagnosed by coronary angiography in our hospital from January 2017 to December 2019 were collected, including 86 patients with PCAD (PCAD group) and 98 patients with non PCAD patients (NPCAD group). Then, 86 healthy patients with male <55 years old and female <65 years old during the same period were selected as the control group. Baseline data of all subjects were collected and levels of fasting blood glucose(FBG), total cholesterol(TC), triglyceride(TG), low-density lipoprotein(LDL), high-density lipoprotein (HDL), serum ZAG, MCP-1 were measured. Pearson correlation was used to analyze the correlation between ZAG, MCP-1 and blood lipid. Multivariate Logistic regression was used to analyze the influencing factors of PCAD. Results: Diabetes history, hypertension history, family history of coronary heart disease, body mass index(BMI), FPG, TG, MCP-1 in the PCAD group, NPCAD group were higher than control group, the levels of HDL, ZAG were lower than control group (P<0.05), The age and levels of HDL, ZAG levels in the PCAD group were lower than the NPCAD group, the proportion of family history of coronary heart disease and smoking history was higher than the NPCAD group(P<0.05). Pearson correlation analysis results showed that ZAG was positively correlated with HDL, and MCP-1 was negatively correlated with HDL(P<0.05). Multivariate Logistic regression analysis showed that hypertension, smoking history, family history of coronary heart disease, HDL, TG, ZAG and MCP-1 were independent risk factors for PCAD. Conclusion: In patients with PCAD, MCP-1 levels increase, ZAG, HDL levels decrease, MCP-1, ZAG and HDL are closely related, and they are independent risk factors for PCAD.