血清铁蛋白（SF）及sod水平与2型糖尿病患者小纤维神经病变关系的研究

摘要 目的：探血清铁蛋白（SF）及超氧化物歧化酶（sod）水平与2型糖尿病患者小纤维神经病变的关系。方法：选择2017年6月至2019年12月我院接诊的120例2型糖尿病患者，根据病变发生情况分为病变组67例，未发生病变53例作为对照组，分析血清铁蛋白（SF）及sod在其中的表达及其预测小纤维神经病变的价值。结果：病变组铁蛋白（SF）水平显著高于对照组，sod水平显著低于对照组，差异显著（P＜0.05）；ROC结果显示，铁蛋白（SF）预测2型糖尿病患者小纤维神经病变的AUC为0.924，95%CI为0.892~0.957，截断值为223.407 ng/mL ；sod预测2型糖尿病患者小纤维神经病变的AUC为0.96，95%CI为0.944~0.987，截断值为126.862 U/mL；联合预测2型糖尿病患者小纤维神经病变的AUC为0.993，95%CI为0.986~1.000，单独检测分别和联合检测曲线下面积比较均具有显著差异，联合检测的特异度、准确度分别为94.26%、95.16%。结论：在2型糖尿病小纤维神经病变患者中血清铁蛋白（SF）及sod的表达异常，对于疾病的进展有诊断意义，临床应给与关注。

Analysis of the Relationship between Serum Ferritin (SF) and SOD Levels and Small Fibroneuropathy in Type 2 Diabetic Patients

ABSTRACT Objective: To study Analysis of theRelationship between serum f Ferritin (SF) and superoxide dismutase (SOD) levels and small fibroneuropathy in type 2 diabetic patients. Methods: 120 patients with type 2 diabetes admitted to our hospital from June 2017 to December 2019 were divided into pathological group (n=67) and control group (n=53) according to the occurrence of pathological changes. The expression of serum ferritin (SF) and SOD in these patients and their value in predicting small fibrous neuropathy were analyzed. Results: The ferritin (SF) level in diseased group was significantly higher than that in control group, and the SOD level was significantly lower than that in control group (P<0.05). ROC results showed that the AUC of ferritin (SF) in predicting small fibrous neuropathy in type 2 diabetic patients was 0.924, 95%CI was 0.892~0.957, and the cutoff value was 223.407 ng/mL. The AUC of SOD in predicting small fibrous neuropathy in type 2 diabetic patients was 0.96, 95%CI was 0.944~0.987, and the cutoff value was 126.862 U/ mL. The AUC and 95%CI for predicting small fibroneuropathy in type 2 diabetes patients were 0.993 and 0.986-1.000, respectively. The area under the curve of single detection was significantly different from that of combined detection, and the specificity and accuracy of combined detection were 94.26% and 95.16%, respectively. Conclusion: The abnormal expression of serum ferritin (SF) and SOD in type 2 diabetic patients with small fibroneuropathy has diagnostic significance for the progression of the disease and should be paid attention to clinically.