子宫内膜癌组织残疾基因同源物2、核连蛋白-2、黏蛋白4的表达及与预后的关系研究

目的:研究子宫内膜癌组织残疾基因同源物2(DAB2)、核连蛋白-2(nucleobindin-2)、黏蛋白4(MUC4)的表达及与预后的关系.方法:将我院从2015年1月～2017年1月收治的子宫内膜癌患者82例纳入研究.分别采集所有患者的子宫内膜癌组织以及癌旁正常组织,以免疫组化法检测不同子宫内膜组织中的DAB2、n...

Expression of Disabled Gene Homologue 2, Nucleoctonin-2 and MUC4 in Endometrial Carcinoma and Its Relationship with Prognosis

Objective:To study the expression of disabled gene homologue 2(DAB2),nucleobindin-2(nucleobindin-2)and MUC4(MUC4)in endometrial carcinoma tissues and its relationship with prognosis.Methods:A total of 82 patients with endometrial cancer who were admitted to our hospital from January 2015 to January 2017 were included in this study.Endometrial cancer tissues and adjacent normal tissues of all patients were collected respectively,and the expressions of DAB2,nucleobindin-2 and MUC4 in different endometrial tissues were detected by immunohistochemistry and compared.The relationship between the positive rates of DAB2,nucleobindin-2,MUC4 and clinicopathological features of endometrial carcinoma were analyzed.In addition,Kaplan-Merier survival curve was used to analyze the relationship between the expression of the above proteins and prognosis,and Cox regression model was used to analyze the risk factors affecting the prognosis of patients with endometrial cancer.Results:The positive rate of DAB2 in endometrial carcinoma was lower than that in adjacent normal tissues,while the positive rates of nucleobindin-2 and MUC4 were higher than those in adjacent normal tissues(all P<0.05).TNM stagingⅢⅣstage,patients with lymph node metastasis of endometrial carcinoma of DAB2 positive rate was lower than the TNM stagingⅠⅡstage,patients with no lymph node metastasis,while the nucleobindin-2,MUC4 positive rate were higher than TNM stagingⅠⅡstage,patients with no lymph node metastasis(all P<0.05).All subjects were followed up for 3-60 months,with a median follow-up time of 31 months.At the end of the follow-up,the progression-free survival rate of patients with DAB2 protein positive was 66.67%(20/30),which was significantly higher than that of patients with DAB2 protein negative of19.23%(10/52).The progression-free survival rates of nucleobindin-2 and MUC4 protein positive patients were 22.95%(14/61)and24.56%(14/57),which were significantly lower than those of 76.19%(16/21)and 64.00%(16/25)in nucleobindin-2 and MUC4 protein negative patients,the differences were statistically significant(all P<0.05).The results of Cox proportional risk regression model showed that TNM stage,lymph node metastasis,DAB2 negative protein,nucleobindin-2 positive protein and MUC4 positive protein were all risk factors for the prognosis of patients with endometrial cancer(all P<0.05).Conclusions:Abnormal low expression of DAB2 and abnormally high expression of nucleobindin-2 and MUC4 in endometrial cancer tissue.Combined detection of the expression of the above three proteins may be helpful for the diagnosis and prognosis evaluation of endometrial cancer.