椎间孔镜下髓核摘除术对腰椎间盘突出患者CK、CRP及腰椎功能恢复的影响

目的:探讨椎间孔镜下髓核摘除术对椎间盘突出患者肌酸激酶(CK)、C反应蛋白(CRP)及腰椎功能恢复的影响.方法:选择2016年10月-2018年8月在我院接受治疗的90例腰椎间盘突出患者,采用抽签法分为椎间孔镜组(n=45)和后路切开组(n=45).对照组给予后路切开髓核摘除手术治疗,观察组给予椎间孔镜下髓核摘除治疗....

Effect of Nucleus Pulposus Excision Under Foramina Lens on CK, CRP and Lumbar Functional Recovery in Patients with Lumbar Disc Herniation

ABSTRACT Objective: To study Effect of nucleus pulposus excision under foramina lens on Creatine kinase (CK), C-reactive protein (CRP) and lumbar functional recovery in patients with lumbar disc herniation. Methods: 90 patients with lumbar disc herniation who were treated in our hospital from October 2016 to August 2018 were selected and divided into intervertebral foramina group (n=45) and posterior incision group (n=45) by lottery. The control group was treated with posterior incision and nucleus pulposus resection, while the observation group was treated with intervertebral foramen. The changes of surgical conditions, CK, CRP, lumbar function, visual analogue scale (VAS) score, Oswestry disability index (ODI) score and complications were compared between the two groups. Results: The operative time of the foramina group was longer than that of the posterior incision group, and the amount of intraoperative blood loss, postoperative time to the ground and hospital stay were lower than that of the posterior incision group (P<0.05). Before surgery, there was no difference in CK and CRP detection results between the two groups. After surgery, CK and CRP in both groups showed an upward trend with time, and the increase in the intervertebral foramina group was lower than that in the posterior incision group (P<0.05). Before operation, there was no difference between the two groups. After surgery, the lumbar curvature and straight leg elevation tests in both groups showed an increasing trend over time, and the increase was more obvious in the foraminal lens group (P<0.05). There was no difference in VAS and ODI scores between the two groups before surgery. After surgery, VAS and ODI scores in both groups showed a downward trend with the passage of time, and the decline was more obvious in the foraminal lens group (P<0.05). After surgery, compared with the posterior incision group (24.44%(11/45), the intervertebral foramina group (4.44%(2/45) was significantly reduced (P<0.05). Conclusion: In patients with lumbar disc herniation, the effect of nucleus pulposus removal under intervertebral foramen microscopy is significant, which can effectively improve CK, CRP and lumbar function level.