穴位针灸联合泼尼松治疗无听力变化耳鸣疗效及对血清5-HT、GABA影响

摘要 目的：探讨穴位针灸联合泼尼松治疗无听力变化耳鸣的疗效及对血清5-羟色胺 （5-hydroxytryptamine，5-HT）、γ-氨基丁酸（Gamma-Amino-Butyric Acid，GABA）影响。方法：选取我院2016年1月~2020年1月所收治的160例无听力变化的耳鸣患者，将其随机分为研究组和对照组，每组患者80例，对照组患者采取波尼松治疗，研究组患者采取穴位针灸联合泼尼松治疗，对比不同治疗方式治疗无听力变化的耳鸣疗效、听力障碍分级以及对血清5-HT、GABA影响。结果：两组治疗前气导平均听阈水平、耳鸣程度对比无统计学差异（P＞0.05），治疗后，研究组气导平均听阈水平、耳鸣程度降低程度较对照组明显（P＜0.05）；研究组的治疗有效率85.00 %明显高于对照组53.75 %（P＜0.05）；研究组的听力恢复正常的人数明显高于对照组（P＜0.05）；中度听力障碍人数对比无显著差异（P＞0.05）；研究组的轻度听力障碍人数明显低于对照组（P＜0.05）；两组治疗前各神经递质含量（5-HT、GABA）对比无统计学差异（P＞0.05），研究组治疗后5-HT、GABA改善程度较对照组更加明显（P＜0.05）。结论：穴位针灸联合泼尼松治疗无听力变化耳鸣的疗效显著，可改善患者的听力、耳鸣，调节中枢性神经递质含量，疗效明显优于单独西医治疗。

Therapeutic Effect of Acupoint Acupuncture Combined with Prednisone on Tinnitus without Hearing Change and Its Effect on Serum 5-HT and GABA

ABSTRACT Objective: To explore the therapeutic effect of acupoint acupuncture combined with prednisone on tinnitus without hearing change and its effect on serum 5-HT and GABA. Methods: A total of 160 patients with tinnitus without hearing change, who were admitted to the Fifth Affiliated Hospital of Xinjiang Medical University from January 2016 to January 2020, were selected and randomly divided into study group(n=80) and control group(n=80). The patients in the control group were treated with polnisone. The patients in the study group were treated with acupuncture and polnisone. The effects of different treatment methods on tinnitus without hearing changes, hearing impairment grades, and their effects on serum 5-HT and GABA were compared between the two groups. Results: Before treatment,there was no significant difference between the two groups (P>0.05). After treatment, the level of the average threshold and tinnitus in the study group was significantly lower than that in the control group (P<0.05). The effective rate(85.00 %) of the study group was higher than that(53.75 %) in the control group(P<0.05). The number of people recovering normal hearing in the study group was significantly higher than that in the control group (P<0.05); there was no significant difference in the number of people with moderate hearing impairment (P>0.05); the number of people with mild hearing impairment in the study group was significantly lower than that in the control group (P<0.05). There was no significant difference in the content of neurotransmitters (5-HT, GABA) between the two groups before treatment (P>0.05). The improvement of 5-HT and GABA in the study group was more significant than that in the control group (P<0.05). Conclusion: Acupoint acupuncture combined with prednisone is effective in the treatment of tinnitus without hearing change. It can improve the patients'' hearing and tinnitus, regulate the content of central neurotransmitter, and its effect is better than western medicine alone.