牛肺磷脂注射液在呼吸窘迫综合征患儿正压通气中的应用

目的:探讨牛肺磷脂注射液联合呼吸机鼻塞式持续正压通气治疗新生儿呼吸窘迫综合征的疗效。方法:98例呼吸窘迫综合征新生儿为研究对象,随机数字法分为两组。对照组应用呼吸机鼻塞式持续正压通气治疗,研究组应用牛肺磷脂注射液联合治疗。结果:研究组有效率高于对照组(P<0.05);治疗前两组患儿的动脉血气指标无明显差异,治疗后,研究组12 h及24 h后的PaO₂、血pH水平高于对照组,PaCO₂水平低于对照组,两组差异有统计学意义(P<0.05);治疗前两组患儿的胸部X线情况对比无明显差异,治疗后,研究组胸部X线各项情况的改善均优于对照组,两组差异有统计学意义(P<0.05);研究组用机时间、住院时间均短于对照组(P<0.05);研究组并发症的发生率低于对照组,两组差异有统计学意义(P<0.05)。结论:牛肺磷脂注射液联合呼吸机鼻塞式持续正压通气治疗新生儿呼吸窘迫综合征效果理想,能够改善患儿的动脉血气指标,提高治疗的效果,缩短患儿的用机及住院时间。

Application of Bovine Lung Phospholipid Injection in Positive Pressure Ventilation in Children with Respiratory Distress Syndrome

Objective:To investigate the clinical study of bovine pulmonary phospholipid injection combined with ventilator continuous positive pressure ventilation in the treatment of neonatal respiratory distress syndrome.Methods:A total of 98 children with respiratory distress syndrome were chosen as research subjects and were randomly divided into two groups.The control group was treated with continuous positive pressure ventilation with nasal congestion with a ventilator,and the study group was treated with bovine lung phospholipid injection on the basis of the control group's therapy.Results:The effective rate of the study group was higher than that of the control group(P<0.05).There was no significant difference in arterial blood gas indexes between the two groups before treatment.12 h and 24 h after treatment,the PaO₂and blood pH levels of the study group were higher than those of the control group,and the PaCO₂level,lower than that of the control group,the difference between the two groups was statistically significant(P<0.05).Before treatment,there was no significant difference in the chest X-ray conditions between the two groups;after treatment,the improvement of the study group's chest X-ray conditions was better than that of the control group,the difference between the two groups was statistically significant(P<0.05).The time of use of the machine and hospital stay of the study group were shorter than those of the control group(P<0.05);the incidence of complications in the study group was lower than that in the control group,the difference between the two groups was statistically significant(P<0.05).Conclusion:In the treatment of neonatal respiratory distress syndrome,the therapeutic effect of bovine pulmonary phospholipid injection combined with ventilator nasal continuous positive pressure ventilation is ideal,which can effectively improve the arterial blood gas index of children,improve the therapeutic effect,shorten the machine and hospital stay of children,and is worthy of clinical application.