阿托伐他汀预处理对心肌缺血再灌注损伤大鼠心室重构、炎症反应和氧化应激的影响

目的:研究阿托伐他汀预处理对心肌缺血再灌注损伤大鼠心室重构、炎症反应和氧化应激的影响.方法:选取90只SD级大鼠进行研究,将其随机分成假手术组、缺血再灌注组、阿托伐他汀组,每组30只.假手术组与缺血再灌注组大鼠予以生理盐水(5 mL/d)连续灌胃7d处理,阿托伐他汀组予以阿托伐他汀20 mg/(kg-d)连续灌胃7 d...

Effects of Atorvastatin Preconditioning on Ventricular Remodeling, Inflammatory Response and Oxidative Stress in Rats with Myocardial Ischemia-reperfusion Injury

Objective:To study the effects of atorvastatin preconditioning on ventricular remodeling,inflammatory response and oxidative stress in rats with myocardial ischemia-reperfusion injury.Methods:90 SD rats were selected for study,they were randomly divided into sham operation group,ischemia-reperfusion group and atorvastatin group,30 in each group.The rats in the sham operation group and the ischemia-reperfusion group were treated with normal saline(5 m L/d)continuous gavage for 7 days.Atorvastatin group was given atorvastatin at 20 mg/(kg·d)continuous gavage for 7 days.After the above intervention,the ischemia-reperfusion group and atorvastatin group established the myocardial ischemia-reperfusion injury model by blocking the left anterior descending branch of the coronary artery.The indexes of ventricular remodeling,inflammatory response and oxidative stress in the three groups were compared.Results:The relative weight of left ventricle,relative weight of right ventricle,ventricular septal thickness,the levels of tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β),malondialdehyde(MDA),lactate deoxidase(LDH)of rats in the ischemia-reperfusion group and atorvastatin group were higher than those in the sham operation group,and all above indexes of rats in the atorvastatin group were lower than the ischemia-reperfusion group(all P<0.05).The levels of interleukin-10(IL-10)and superoxide gasification enzyme(SOD)of rats in the ischemia-reperfusion group and atorvastatin group were lower than those in the sham operation group,and the levels of IL-10,SOD in the atorvastatin group were higher than the ischemia-reperfusion group(all P<0.05).Conclusion:Atorvastatin preconditioning can effectively prevent ventricular remodeling in rats with myocardial ischemia-reperfusion injury,and improve the inflammatory response and oxidative stress in rats to a certain extent.