脑血康胶囊联合巴曲酶对急性脑梗死患者血清 MBP、NSE水平的影响

摘要 目的：研究脑血康胶囊联合巴曲酶对急性脑梗死患者血清髓鞘碱性蛋白(myebin bosic protein，MBP)、神经元特异性烯醇化酶(neuron-specific enolase，NSE)水平的影响。方法：选择2018年3月～2019年3月我院收治的161例急性脑梗死患者，将其随机分为两组。对照组静脉滴注巴曲酶，首次给予10 BU，隔日给予5 BU，每两天给药1次；观察组在巴曲酶的基础上联合口服脑血康胶囊，每天3 次，每次3粒。观察和比较两组治疗总有效率、治疗前后血清MBP、NSE、全血黏度(whole blood viscosity，WBV)、红细胞压积(hematocrit，HCT)、血浆黏度(plasma viscosity，PV)和纤维蛋白原(fibrinogen，FIB)水平及NHISS和BI评分的变化。结果：治疗后，观察组的有效率为91.25 %，明显高于对照组(64.2%，P<0.05)；两组血清MBP、NSE、WBV、HCT、PV和FIB水平均较治疗前明显降低(P<0.05)，且观察组的以上指标明显低于对照组(P<0.05)；两组的BI评分明显升高(P<0.05)，NHISS评分明显降低(P<0.05)，观察组BI评分明显高于对照组，而NHISS评分明显低于对照组(P<0.05)。结论：脑血康胶囊联合巴曲酶对急性脑梗死有显著的疗效，能明显降低患者血清MBP、NSE水平，促进神经功能的恢复。

Effect of Naoxuekang Capsule Combined with Batroxobin on the Serum MBP and NSE Levels of Patients with Acute Cerebral Infarction

ABSTRACT Objective: To investigate the effect of Naoxuekang capsule combined with batroxobin on serum MBP and NSE levels in patients with acute cerebral infarction. Methods: Selected 161 cases of patients with acute cerebral infarction who were treated in our hospital from March 2018 to March 2019, divided into two groups randomly. In the control group, batroxobin was given intravenously, 10 BU for the first time, 5 BU for the next day, once every two days; in the observation group, Naoxuekang capsule was taken orally on the basis of batroxobin, three times a day, three capsules each time. Observe and compare the total treatment efficiency, serum MBP, NSE, whole blood viscosity (WBV), hematocrit (HCT), plasma viscosity (PV) and fibrinogen before and after treatment fibrinogen (FIB) levels and changes in NHISS and BI scores. Results: After treatment, the effective rate of the observation group was 91.25 %, which was significantly higher than that of the control group (64.2 %, P<0.05). Serum MBP, NSE, WBV, HCT, PV and FIB levels in the two groups were significantly lower than before treatment (P<0.05), and the above indicators in the observation group were significantly lower than those in the control group (P<0.05). The BI score of the two groups was significantly increased (P<0.05), the NHISS score was significantly decreased (P<0.05), the BI score of the observation group was significantly higher than that of the control group, and the NHISS score was significantly lower than that of the control group (P<0.05). Conclusion: Naoxuekang capsule combined with batroxobin had a significant effect on acute cerebral infarction, could significantly reduce the level of serum MBP, NSE, and promote the recovery of nerve function.