Contribution to investigation of antimicrobial activity of styrylquinolines |
| |
| Authors: | Wioleta Cieslik Robert Musiol Jacek E Nycz Josef Jampilek Marcela Vejsova Mariusz Wolff Barbara Machura Jaroslaw Polanski |
| |
| Institution: | 1. Institute of Chemistry, University of Silesia, PL-40006 Katowice, Poland;2. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, CZ-61242 Brno, Czech Republic;3. Research Institute for Pharmacy and Biochemistry, Lidicka 1879/48, CZ-60200 Brno, Czech Republic;4. Department of Clinical Microbiology, Charles University Medical School and Teaching Hospital, Sokolska 581, Hradec Kralove 50005, Czech Republic |
| |
| Abstract: | Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure–activity relationships are discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
