帕拉米韦氯化钠注射液对流感病毒A型肺炎患儿的成本-效益分析

目的:探讨帕拉米韦氯化钠注射液对流感病毒A型肺炎患儿的成本-效益.方法:选择我院2015年1月至2018年12月收治的96例流感病毒A型肺炎患儿,根据随机数字表法,将96例患儿分为A组及B组,每组48例,A组患儿给予磷酸奥司他韦颗粒,B组患儿给予帕拉米韦氯化钠注射液,对比两组患儿的治疗效果、临床症状消失时间、住院时间、...

The Cost-benefit Analysis of Peramivir Sodium Chloride Injection in Children with Influenza Virus Type A Pneumonia

ABSTRACT Objective: To investigate the cost-benefit analysis of peramivir sodium chloride injection in children with influenza virus type A pneumonia. Methods: 96 children with influenza virus A pneumonia admitted to our hospital from January 2015 to December 2018 were selected, who were divided into two groups according to the random number table method, each group had 48 cases, group A were given Oseltamivir phosphate granules, group B were given Peramivir sodium chloride injection, the treatment effect, clinical symptoms disappearance time, stay length , medication cost, cost-benefit in two groups were compared, the blood routine and liver and kidney function before and after treatment were compared in two groups, and the incidence of adverse reactions was compared between the two groups. Results: The effective rate of treatment in group B was significantly higher than that in group A (P<0.05). The average drug cost of group A was significantly lower than that of group B(P<0.05), and the cost-benefit of group A was lower than that of group B(P<0.05). Compared with before treatment, the total number of neutrophils was significantly increased, and the total number of white blood cells and lymphocytes were significantly decreased in two groups after treatment(P<0.05). Before and after treatment, there were no statistical significance in blood routine indexes of two groups (P>0.05). Before and after treatment, there was no statistical significance in liver and kidney function of two groups(P>0.05). The incidence of adverse reactions in group B was higher than that in group A, but the comparison between groups was not statistically significant(P>0.05). Conclusion: Compared with Oseltamivir phosphate, Peramivir sodium chloride injection has better efficacy in the treatment of children with influenza virus type A pneumonia, while the cost-benefit was low, and medication could be selected according to the actual situation of children.