早期康复对ICU获得性肌无力患者肌力改善、细胞免疫因子及睡眠质量的影响

目的:探讨早期康复对ICU获得性肌无力(ICU-AW)患者肌力改善、细胞免疫因子及睡眠质量的影响.方法:纳入2017年1月～2020年8月我院收治的ICU-AW患者146例,依照随机数字表法分为观察组(n=73)和对照组(n=73).对照组给予常规干预,观察组给予常规干预联合早期康复.康复前后,考察两组肌力改善、气道阻...

Effect of Early Rehabilitation on Muscle Strength Improvement, Cellular Immune Factors and Sleep Quality in Patients with Intensive Care Unit-Acquired Weakness

ABSTRACT Objective: To investigate the effect of early rehabilitation on muscle strength improvement, cellular immune factors and sleep quality in patients with Intensive Care Unit-Acquired Weakness(ICU-AW). Methods: 146 patients with ICU-AW admitted to our hospital from January 2017 to August 2020 were selected and randomly divided into observation group (n=73) and control group (n=73). The control group was given routine intervention, and the observation group was given routine intervention combined with early rehabilitation. Before and after rehabilitation, the improvement of muscle strength, airway obstruction, sleep status and serum levels of CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ were observed. Results: The scores of muscle strength and PSQI score in the observation group after rehabilitation were lower than those in the control group, and the differences were statistically significant (P<0.05). The proportion of central airway and peripheral airway obstruction in the observation group after rehabilitation was lower than that in the control group, and the differences were statistically significant (P<0.05). The levels of serum CD3⁺, CD4⁺, CD4⁺/CD8⁺ in the observation group after rehabilitation were lower than those in the control group, and the level of CD8⁺ in the observation group was higher than that in the control group, the differences were statistically significant(P<0.05). Conclusion: Early rehabilitation can effectively improve the muscle strength of ICU-AW patients, relieve airway obstruction, correct the imbalance of cellular immune factors, and improve sleep quality, which is worthy of clinical recommendation.