帕瑞昔布钠复合舒芬太尼对甲状腺手术患者术后镇痛镇静效果、血流动力学及炎症反应的影响

目的:探讨帕瑞昔布钠复合舒芬太尼对甲状腺手术患者术后镇痛镇静效果、血流动力学及炎症反应的影响.方法:选择2018年6月～2019年6月期间100例在我院择期行甲状腺手术患者,根据随机数字表法分为对照组(n=50,术后镇痛予以舒芬太尼)和研究组(n=50,术后镇痛予以帕瑞昔布钠复合舒芬太尼),比较两组患者术后镇痛镇静效果...

Effects of Parecoxib Sodium Sombined with Sufentanil on Postoperative Analgesia, Sedation Effect, Hemodynamics and Inflammatory Response in Patients Undergoing Thyroid Surgery

Objective: To investigate the effects of parecoxib sodium combined with sufentanil on postoperative analgesia, sedation effect, hemodynamics and inflammatory response in patients undergoing thyroid surgery. Methods: From June 2018 to June 2019,100 patients who underwent elective thyroid surgery in our hospital were selected. The patients were divided into two groups: control group(n=50, sufentanil was given for postoperative analgesia) and the study group(n=50, parexibna combined with sufentanil was given for postoperative analgesia). The effects of postoperative analgesia, sedation, hemodynamics, inflammatory responses and adverse reactions were compared between the two groups. Results: The visual pain analogue scale(VAS) in the two groups at 8 h, 16 h and 24 h after operation increased and then decreased, and that in the study group was lower than that in the control group(P<0.05). The Ramsay sedation scores of the two groups at 8 h, 16 h and 24 h after operation decreased and then increased, and that in the study group was higher than that in the control group(P<0.05). The heart rate(HR) and mean arterial pressure(MAP) of the patients in the control group at 8 h,16 h and 24 h after operation decreased and then increased(P<0.05). There was no significant difference in MAP, HR between 8 h, 16 h and 24 h after operation and immediately after operation in the study group(P>0.05). The MAP and HR in the study group were higher than those in the control group(P<0.05). The levels of interleukin-6(IL-6), C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α)in the two groups at 6 h and 24 h after operation increased and then decreased, however, those in the study group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion: In postoperative analgesia of patients undergoing thyroid surgery, parecoxib sodium combined with sufentanil can obtain better analgesic effect, able to maintain hemodynamic stability, reduce inflammatory reaction of the body, and it do not increase the incidence of adverse reactions.