色素内镜联合CRP和TRF在青海地区早期食管癌患者的诊断价值

摘要 目的：探讨色素内镜联合C反应蛋白(C-reactive protein，CRP)和转铁蛋白(Transferrin，TRF)在青海地区早期食管癌患者的诊断价值。方法：2018年6月至2020年3月选择在本院进行食管癌筛查的青海地区患者250例，所有患者都给予色素内镜检查，同时给予血浆CRP和TRF检查并判断诊断价值。结果：在250例患者中，病理诊断为原位癌28例，高级别上皮内瘤变10例，低级别上皮内瘤变12例，慢性炎症200例；其中早期食管癌38例。卢戈液色素内镜显示不染色47例，淡染色95例，浓染色108例。早期食管癌患者的血浆CRP值都高于非早期食管癌患者，TRF值低于(P<0.05)。Pearson相关性分析显示早期食管癌与色素内镜卢戈液不染色、CRP、TRF值存在相关性(P<0.05)。色素内镜联合CRP和TRF在青海地区早期食管癌的诊断敏感性与特异性分别为97.4 %和100.0 %。结论：色素内镜联合CRP和TRF在青海地区早期食管癌患者诊断中的应用具有很好的敏感性与特异性，能有效预测早期食管癌发生情况，对早期诊治早期食管癌具有一定的指导意义。

Diagnostic Values of Pigment Endoscopy Combined with CRP and TRF in Patients with Early Esophageal Cancer in Qinghai District

ABSTRACT Objective: To investigate the diagnostic values of pigment endoscopy combined with C-reactive protein (CRP and transferrin(TRF) in patients with early esophageal cancer in Qinghai district. Methods: June 2018 to March 2020, 250 cases of patients in Qinghai district who were selected for esophageal cancer screening in our hospital, all the cases were all given endoscopy, and plasma CRP and TRF were detected, and were also given to determine the diagnostic values. Results: The pathological diagnosis were 28 case were carcinoma in situ, 10 with cases were high-grade intraepithelial neoplasia, 12 cases were low-grade intraepithelial neoplasia, and 200 cases were chronic inflammation that there were 38 cases were early esophageal cancer. Pigment endoscopy showed 47 cases without staining, 95 cases with light staining, 108 cases with concentrated staining. The plasma CRP value of patients with early esophageal cancer were higher than that of patients with non-early esophageal cancer, the TRF value were lower (P<0.05). Pearson correlation analysis showed that pigment endoscopy without staining, CRP and TRF values were correlated to the early esophageal cancer in Qinghai district(P<0.05). The diagnostic sensitivity and specificity of pigment endoscopy combined with CRP and TRF in early esophageal cancer in Qinghai were 97.4 % and 100.0 %, respectively. Conclusion: The application of pigment endoscopy combined with CRP and TRF in the diagnosis of patients with early esophageal cancer in Qinghai have good sensitivity and specificity, they can effectively predict the occurrence of early esophageal cancer, and have certain guiding significance for early diagnosis and treatment of early esophageal cancer.