雷珠单抗联合复合式小梁切除术及全视网膜光凝术对新生血管性青光眼患者视功能及房水炎症因子的影响

目的:探讨复合式小梁切除术及全视网膜光凝术联合雷珠单抗对新生血管性青光眼(NVG)患者视功能及房水炎症因子的影响。方法:选取2017年2月~2019年9月期间我院收治的NVG患者156例,上述患者根据随机数字表法分为对照组(n=78)和研究组(n=78),对照组患者给予复合式小梁切除术及全视网膜光凝术治疗,研究组则在对照组的基础上联合雷珠单抗治疗,比较两组患者疗效、最佳矫正视力、眼压及房水炎症因子,记录两组患者术后并发症发生率。结果:研究组术后6个月的临床总有效率为88.46%(69/78),高于对照组的67.95%(53/78)(P<0.05)。研究组术后1个月、术后3个月、术后6个月最佳矫正视力高于对照组,眼压则低于对照组(P<0.05)。两组患者术后6个月单核细胞趋化蛋白1(MCP-1)、白介素-1β(IL-1β)、白介素-6(IL-6)均下降,且研究组低于对照组(P<0.05)。研究组的并发症总发生率为8.97%(7/78)低于对照组21.79%(17/78)(P<0.05)。结论:雷珠单抗联合复合式小梁切除术及全视网膜光凝术治疗NVG,疗效显著,可有效改善患者视功能及房水炎症因子,同时还可减少术后并发症发生率。

The Effect of Combined Trabeculectomy and Panretinal Photocoagulation with Razumab on the Visual Function and Inflammatory Factors of Aqueous Humor in Patients with Neovascular Glaucoma

Objective: To investigate the effect of compound trabeculectomy and retinal photocoagulation combined with leizhumab on the visual function and aqueous inflammatory factors in patients with neovascular glaucoma(NVG). Methods: 156 NVG patients in our hospital from February 2017 to September 2019 were selected. The above patients were divided into the control group(n=78) and the study group(n=78) according to the method of random number table. The patients in the control group were treated with compound trabeculectomy and panretinal photocoagulation. The study group was combined with leizhumab on the basis of the control group. The curative effect, the best corrected vision, intraocular pressure and inflammatory factors of aqueous humor between the two groups were compared, the incidence of postoperative complications was recorded. Results: The total clinical effective rate of the study group was 88.46%(69/78), which was higher than 67.95%(53/78) of the control group(P<0.05). The best corrected visual acuity of the study group was higher than that of the control group at 1 month, 3 months and 6 months after operation, and the intraocular pressure was lower than that of the control group(P<0.05). The levels of monocyte chemoattractant protein-1(MCP-1), interleukin-1 β(IL-1β),interleukin-6(IL-6) in the study group were lower than those in the control group(P<0.05). The total incidence of complications in the study group was 8.97%(7/78) lower than 21.79%(17/78) in the control group(P<0.05). Conclusion: Combined trabeculectomy and retinal photocoagulation can improve the visual function and inflammatory factors of aqueous humor, and reduce the incidence of postoperative complications.