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The impact of quasispecies dynamics on the use of therapeutics
Authors:Celia Perales  Jaime Iranzo  Susanna C. Manrubia  Esteban Domingo
Affiliation:1. Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Campus de Cantoblanco 28049, Madrid, Spain;2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08036 Barcelona, Spain;3. Centro de Astrobiología (INTA-CSIC), Instituto Nacional de Técnica Aeroespacial, Carretera de Ajalvir km 4, 28850 Torrejón de Ardoz, Madrid, Spain;1. Grupo Interdisciplinar de Sistemas Complejos (GISC), Spain;2. Departamento de Matemáticas, Universidad Carlos III de Madrid, Spain;3. Institute for Biocomputation and Physics of Complex Systems, Zaragoza, Spain;4. UC3M-BS Institute of Financial Big Data (IFiBiD), Spain;5. National Biotechnology Centre (CSIC), Madrid, Spain;1. Servicio de Atención Primaria Camp de Tarragona, Institut Català de la Salut, Tarragona, Spain;2. Instituto Universitario de Investigación en Atención Primaria Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain;1. Wroc?aw University of Technology, Faculty of Microsym Electronics and Photonics, Janiszewskiego str. 11/17, 50-372 Wroc?aw, Poland;2. The National Center for Scientific Research, LAAS, BP 54200, 31031 Toulouse cedax 4, France;3. Univ de Toulouse, LAAS, F-31400 Toulouse, France;4. National Center for Nuclear Research, Radiation Detection Physics Division, Andrzeja So?tana str. 7, 05-400 Otwock, Poland;1. Department of Internal Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium;2. Department of Microbiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium;3. Department of General Internal Medicine and Infectious Diseases, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium;4. Department of Geriatric Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
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