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BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor

Authors:	Andreas Gerondopoulos Lars Langemeyer Jin-Rui Liang Andrea Linford Francis A Barr

Institution:	1. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK;2. Wellcome Trust PhD Programme in Cellular and Molecular Physiology, Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK

Abstract:	Download : Download high-res image (362KB) Download : Download full-size image Highlights? The Hps1-Hps4 complex (BLOC-3) is a guanine nucleotide exchange factor (GEF) ? Purified BLOC-3 has specific GEF activity toward Rab32 and Rab38 ? BLOC-3 can promote recruitment of Rab32 and Rab38 to membranes ? BLOC-3 and its target Rabs act in the biogenesis of melanosomes

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