Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

Authors:	Cho Yeow Koh Jessica E Kim Sayaka Shibata Ranae M Ranade Mingyan Yu Jiyun Liu J Robert Gillespie Frederick S Buckner Christophe LMJ Verlinde Erkang Fan Wim GJ Hol

Institution:	1. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA;2. Department of Chemistry, University of Washington, Seattle, WA 98195, USA;3. Department of Medicine, University of Washington, Seattle, WA 98195, USA;4. Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, P.R. China

Abstract:	Download : Download high-res image (270KB) Download : Download full-size image Highlights? Complexes of MetRS from T. brucei with its substrate, intermediate, and inhibitors ? In crystals, substrate-bound MetRS undergoes extensive changes with inhibitor binding ? The inhibitor-bound conformation is surprisingly similar to the ligand-free state ? This indicates inhibitor binding occurs via conformational selection not by induced fit

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