补阳还五汤联合强力定眩片对后循环缺血性眩晕患者眩晕症状、氧化应激及血流指标的影响

目的:探讨补阳还五汤联合强力定眩片对后循环缺血(PCI)性眩晕患者眩晕症状、氧化应激及血流指标的影响。方法:选取中国中医科学院西苑医院于2018年12月~2019年12月间接收的80例PCI性眩晕患者,采用信封法将患者随机分为对照组(n=40,常规西医治疗)和研究组(n=40,常规西医基础上增加补阳还五汤联合强力定眩片治疗),比较两组患者临床疗效、眩晕症状、氧化应激及血流指标,记录两组治疗期间不良反应发生情况。结果:治疗2个疗程后,研究组的总有效率高于对照组(P<0.05)。两组患者治疗2个疗程后眩晕障碍量表(DHI)评分、超氧化物歧化酶(SOD)、一氧化氮(NO)水平、椎动脉平均血流速度、基底动脉平均血流速度均升高,且研究组高于对照组(P<0.05);两组丙二醛(MDA)水平、全血黏度、血浆黏度、红细胞压积均降低,且研究组低于对照组(P<0.05)。两组不良反应发生率比较无差异(P>0.05)。结论:补阳还五汤联合强力定眩片治疗PCI性眩晕患者,可改善患者眩晕症状及血流状况,降低机体氧化应激程度,疗效确切,且用药安全性较好。

Effects of Buyang Huanwu Decoction and Qiangli Dingxuan Tablet on Vertigo Symptoms, Oxidative Stress and Blood Flow Index in Poaterior Circulation Ischemia Vertigo Patients

Objective: To investigate the effects of Buyang Huanwu Decoction combined with Qiangli Dingxuan tablet on vertigo symptoms, oxidative stress and blood flow indexes in patients with poaterior circulation ischemia(PCI) vertigo. Methods: 80 patients with PCI vertigo who were admitted to Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine from December 2018 to December 2019 were selected as the research objects, the patients were divided into control group(n=40, Conventional western medicine treatment) and study group(n=40, Buyang Huanwu Decoction Combined with qianglidingxuan tablet on the basis of Conventional western medicine treatment) by envelope method. The clinical efficacy, vertigo symptoms, oxidative stress and blood flow indexes of the two groups were compared, adverse reactions were recorded during the treatment of in the two groups. Results: The total effective rate of the study group was 90.00%(36/40) after two courses of treatment, which was higher than 70.00%(28/40) of the control group(P<0.05).After two courses of treatment, the dizziness handicap inventory(DHI), superoxide dismutase(SOD), nitric oxide(NO), vertebral artery mean blood flow velocity, basilar artery mean blood flow velocity of the two groups increased, and the study group was higher than the control group(P<0.05). The visual simulation scale(VAS), malondialdehyde(MDA), whole blood viscosity, plasma viscosity, hematocrit of the two groups decreased, and the research group were lower than those of the control group(P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Using Buyang Huanwu Decoction combined with Qiangli Dingxuan Tablet to treat patients with PCI vertigo, improve the clinical symptoms and blood flow of patients with PCI vertigo, reduce the degree of oxidative stress in the body, has a definite curative effect, and the safety of medication is good.