加味麻杏石甘汤联合噻托溴铵对慢性阻塞性肺疾病急性加重期患者肺功能、血气指标及炎症因子的影响

目的:探讨加味麻杏石甘汤联合噻托溴铵对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能、血气指标及炎症因子的影响.方法:选取2018年2月-2019年11月我院收治的97例AECOPD患者,按随机数字表法将其分为对照组(n=48,噻托溴铵治疗)、研究组(n=49,加味麻杏石甘汤联合噻托溴铵治疗),比较两组患者疗效、...

Effect of Modified Maxingshigan Decoction Combined with Tiotropium Bromide on Pulmonary Function, Blood Gas Index and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

ABSTRACT Objective: To investigate the effect of modified Maxingshigan decoction combined with tiotropium bromide on pulmonary function, blood gas index and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 97 patients with AECOPD in our hospital from February 2018 to November 2019 were selected, they were divided into control group (n=48, tiotropium bromide treatment) and study group (n=49, modified Maxingshigan decoction and tiotropium bromide treatment) by random number table method. The therapeutic effect, TCM syndrome score, lung function, blood gas index, inflammatory factors and adverse reactions were compared between the two groups. Results: 14 d after treatment, the total clinical effective rate of the study group was higher than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). The scores of TCM syndromes in the two groups 14 d after treatment decreased, and the study group was lower than the control group(P<0.05). The forced expiratory volume at 1 second (FEV₁), forced vital capacity (FVC) and FEV₁/ FVC at 14 d after treatment in the two groups were higher than those before treatment, and the study group was higher than control group (P<0.05). 14 d after treatment, the arterial oxygen partial pressure (PO₂) of the two groups increased, and the study group was higher than that of the control group (P<0.05), and the partial pressure of carbon dioxide (PCO₂) of the study group was lower than that of the control group (P<0.05). The levels of interleukin-8 (IL-8), c-reactive protein (CRP) in the two groups decreased at 14 d after treatment, and the level in the study group was lower than that in the control group (P<0.05). Conclusion: Modified Maxingshigan decoction combined with tiotropium bromide is effective in the treatment of AECOPD, which can effectively improve the clinical symptoms, lung function, blood gas index and inflammatory factors, and is safe and reliable.