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ATP-Driven Remodeling of the Linker Domain in the Dynein Motor
Authors:Anthony J Roberts  Bara Malkova  Matt L Walker  Hitoshi Sakakibara  Naoki Numata  Takahide Kon  Reiko Ohkura  Thomas A Edwards  Peter J Knight  Kazuo Sutoh  Kazuhiro Oiwa  Stan A Burgess
Institution:1. Astbury Centre for Structural Molecular Biology, Institute of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK;2. MLW Consulting, 11 Race Hill, Launceston, Cornwall PL15 9BB, UK;3. National Institute of Information and Communications Technology, Advanced ICT Research Institute, 588-2 Iwaoka, Nishi-ku, Kobe 651-2492, Japan;4. Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba 3-8-1, Tokyo 153-8902, Japan
Abstract:
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  • Highlights? Structural changes in axonemal and cytoplasmic dynein motors seen by cryo-EM ? Movement is amplified by a hinge action within dynein's linker domain ? The linker is a stable structure that is actively remodeled by dynein's AAA+ modules ? Dynein's neck subdomain interacts with AAA4 and is an intrinsic site of flexibility
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