氨基酸转运载体ASCT2和LAT1在胃癌组织的表达及其临床价值

摘要 目的：研究ASC型氨基酸转运体2（ASCT2）和L型氨基酸转运体1（LAT1）在胃癌组织中的表达情况，并探讨其临床价值。方法：收集70例进展期胃癌组织以及相对应的肿瘤旁组织，采用免疫组化方法检测ASCT2和LAT1在相应组织中的表达水平，并研究其表达与患者临床病理参数和预后的相关性。结果：与癌旁组织相比，胃癌组织中ASCT2或LAT1的高表达率均有统计学差异，但其各自的表达率与癌旁组织相比无明显差异。LAT1和ASCT2在胃癌组织中的共表达率与癌旁组织相比有明显统计学差异。胃癌组织中ASCT2高表达与肿瘤体积、T分期、N分期、TNM分期和Ki-67指数显著相关；LAT1的高表达与肿瘤体积、N分期和TNM分期相关。胃癌组织中ASCT2与LAT1共表达与肿瘤体积、T分期、N分期、TNM分期和Ki-67指数显著相关。胃癌组织中ASCT2和LAT1的高表达呈正相关。胃癌组织中ASCT2高表达、LAT1高表达及ASCT2与LAT1共表达与患者不良预后有关。结论：胃癌组织中ASCT2高表达、LAT1高表达以及ASCT2与LAT1共表达提示患者预后不良，有一定临床价值。

The Clinical Value of Amino Acid Transporters ASCT2 and LAT1 in Gastric Cancer

ABSTRACT Objective: To observe the expression of ASCT2 and LAT1 protein in gastric cancer tissues and analyze its clinical value. Methods: The expression of ASCT2 and LAT1 in 70 cases of advanced gastric cancer tissues and its adjacent tissues were detected by immunohistochemistry, and the relationship between the expression and the clinical characteristics and prognosis of patients with gastric cancer was analyzed. Results: Compared with the paracancerous tissues, the high expression rates of ASCT2 or LAT1 in gastric cancer tissues were statistically different, but there was no significant difference in their respective expression rates in gastric cancer tissues compared with the paracancerous tissues. The coexpression rate of LAT1 and ASCT2 in gastric cancer tissues was significantly different from that in adjacent tissues. The high expression of ASCT2 was significantly correlated with tumor size, depth of invasion, lymph node metastasis, TNM stage and Ki-67 index, while the high expression of LAT1 was only correlated with tumor size, lymph node metastasis and TNM stage. The coexpression of ASCT2 and LAT1 was significantly correlated with tumor size, depth of invasion, lymph node metastasis, TNM stage and Ki-67 index. The high expression of ASCT2 in gastric cancer tissues was significantly correlated with the high expression of LAT1 in gastric cancer tissues. The high expression of ASCT2 or LAT1 in gastric cancer tissues and the coexpression of ASCT2 and LAT1 in gastric cancer tissues were related to the poor prognosis. Conclusion: The high expression of ASCT2 or LAT1 and the coexpression of ASCT2 and LAT1 in gastric cancer tissues were associated with poor prognosis in patients with gastric cancer, which has some practical value.