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Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients
Authors:Milka Sarris  Jean-Baptiste Masson  Damien Maurin  Lieke M Van der Aa  Pierre Boudinot  Hugues Lortat-Jacob  Philippe Herbomel
Institution:1. Macrophages and Development of Immunity Unit, Department of Developmental and Stem Cell Biology, Institut Pasteur, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France;2. Physics of Biological Systems Unit, Institut Pasteur, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France;3. CNRS, URA 2578, 75015 Paris, France;4. CNRS, URA 2171, 75015 Paris, France;5. CEA, CNRS, Université Joseph Fourier Grenoble 1, SAGAG Group, Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075, 38000 Grenoble, France;6. Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy-en-Josas, France;7. Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
Abstract:
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  • Highlights? Chemokines form tissue-bound gradients in vivo through heparan sulfate proteoglycans ? Chemokines guide neutrophils in vivo as haptotactic gradients ? Chemokines guide neutrophils toward infection loci by triggering orthotaxis ? Chemokines locally restrict neutrophil motility at sites of infection
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