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DNA Minor Groove Sensing and Widening by the CCAAT-Binding Complex

Authors:	Eva M Huber Daniel H Scharf Peter Hortschansky Michael Groll Axel A Brakhage

Institution:	1. Center for Integrated Protein Science, Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, Garching 85747, Germany;2. Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Jena 07745, Germany;3. Department of Microbiology and Molecular Biology, Friedrich Schiller University, Jena 07745, Germany

Abstract:	Download : Download high-res image (287KB) Download : Download full-size image Highlights? CBC binds to the minor groove of the DNA and bends it in a nucleosome-like manner ? Interactions of subunit HapB with DNA explain the sequence specificity of the CBC ? Anchor A of HapB tethers the CBC to the CCAAT box by minor groove widening ? Interactions of the CBC with the histones H3/H4 of the nucleosome are modeled

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