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Structure of an Asymmetric Ternary Protein Complex Provides Insight for Membrane Interaction
Authors:Brian R Dempsey  Atoosa Rezvanpour  Ting-Wai Lee  Kathryn R Barber  Murray S Junop  Gary S Shaw
Institution:1. Department of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada;2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Abstract:
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  • Highlights? S100A10, annexin A2, and AHNAK are involved in membrane repair ? The AHNAK binding region forms a coiled structure ? Both S100A10 and annexin A2 make contacts to AHNAK and are necessary for binding ? The asymmetric architecture provides a model for AHNAK translocation to the membrane
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