Discovery of 6-[4-(6-nitroxyhexanoyl)piperazin-1-yl)]-9H-purine,as pharmacological post-conditioning agent |
| |
| Authors: | Maria Koufaki Theano Fotopoulou Efstathios K Iliodromitis Sophia-Iris Bibli Anastasia Zoga Dimitrios Th Kremastinos Ioanna Andreadou |
| |
| Institution: | 1. National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48, Vas. Constantinou Ave. 11635 Athens, Greece;2. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupolis-Zografou, 15771 Athens, Greece;3. Second University Department of Cardiology, Medical School, Attikon General Hospital, University of Athens, 12462 Athens, Greece |
| |
| Abstract: | Novel purine analogues bearing nitrate esters were designed and synthesized in an effort to develop compounds triggering endogenous cardioprotective mechanisms such as ischemic preconditioning (IPC) or postconditioning (PostC). The majority of the compounds reduced infarct size compared to the control group in anesthetized rabbits, whereas administration of the most active analogue 16 at a dose of 3.8 μmol/kg resulted on a significant reduction of infarct size, compared to PostC group (13.4 ± 1.9% vs 26.4 ± 2.3%). These findings introduce a novel class of promising pharmacological compounds that could be used as mimics or enhancers of PostC. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
