伴与不伴边缘性人格障碍的首发中青年抑郁症患者认知功能、临床症状的差异及其相关性分析

目的:比较伴与不伴有边缘性人格障碍(BPD)的首发中青年抑郁症患者认知功能及临床症状的差异,并分析相关性。方法:选取自2017年3月至2020年1月于我院就诊的首发中青年抑郁症患者167例,按照纳入标椎及排除标椎,剔除21例不符合者,最终入组146例。将伴有BPD的抑郁症患者归为研究组(72例),不伴有BPD的抑郁症患者归为对照组(74例)。采用韦氏记忆量表(WMS-RC)、韦氏智能量表(WAIS-RC)、威斯康星卡片分类测验(WCST)对两组患者进行认知功能的对照性评估,采用症状自评量表(SCL-90)评估患者临床症状,Pearson相关性分析患者认知功能与临床症状的关系。结果:研究组的人际关系敏感因子评分较对照组升高(P<0.05)。研究组即刻记忆、语言智商数、操作智商数评分均低于对照组,而持续错误数多于对照组(P<0.05)。经Pearson相关性分析可得:伴有BPD的首发中青年抑郁症患者人际关系敏感因子评分与即刻记忆、语言智商数、操作智商数均呈负相关关系(P<0.05),而与持续错误数呈正相关关系(P<0.05)。结论:伴有BPD的首发中青年抑郁症患者较不伴有BPD的抑郁症患者认知功能受损更为严重,人际关系敏感性更高,且患者的认知功能与临床症状存在一定的关联。

The Difference and Correlation Analysis of Cognitive Function and Clinical Symptoms of First-episode Young in Middle-aged Depression Patients with and without Borderline Personality Disorder

ABSTRACT Objective: To compare the differences of cognitive function and clinical symptoms between the first-episode young in middle-aged depression patients with and without borderline personality disorder(BPD). Methods: 167 patients with first-episode depression were selected in our hospital from March 2017 to January 2020. 21 patients were excluded according to the standard vertebra, and 146 patients were finally enrolled. The patients with BPD were divided into study group (72 cases) and control group (74 cases). Wechsler Memory Scale (WMS-RC), Wechsler Intelligence Scale (WAIS-RC), Wisconsin Card Sorting Test (WCST) were used to assess the cognitive function of the patients in the study group and the control group, and the symptom checklist 90 (SCL-90) was used to assess the patient''s clinical symptoms. The relationship between cognitive function and clinical symptoms was analyzed by Pearson correlation analysis. Results: The interpersonal sensitivity factor score of the study group was higher than that of the control group (2.22±0.21) (P<0.05). The scores of immediate memory, verbal IQ and operational IQ in the study group were lower than those in the control group, while the number of persistent errors was more than that in the control group (P<0.05). Pearson correlation analysis showed that interpersonal sensitivity of first-episode young in middle-aged depression patients with BPD was negatively correlated with immediate memory, verbal IQ and operational IQ(P<0.05), while positively correlated with persistent error number (P<0.05). Conclusion: The first-episode young in middle-aged depression patients with BPD is more serious than that of patients without BPD, and the interpersonal relationship sensitivity of patients with BPD is higher than that of patients without BPD, and there is a certain correlation between cognitive function and clinical symptoms.