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Allosteric Mechanism Controls Traffic in the Chaperone/Usher Pathway
Authors:Xiao Di Yu  Anatoly Dubnovitsky  Alex F Pudney  Sheila MacIntyre  Stefan D Knight  Anton V Zavialov
Institution:1. Department of Molecular Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences, BMC, Box 590, SE-753 24 Uppsala, Sweden;2. Department of Chemistry, University of Turku, Turku, JBL, BioCity 6A, FIN-20520 Turku, Finland;3. School of Biological Sciences, Animal and Microbial Sciences Building, University of Reading, Reading RG6 6AJ, UK
Abstract:
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  • Highlights? Allosteric mechanism controls traffic in the chaperone/usher pathway ? Usher-binding site in free chaperone is conformationally locked ? Subunit binding opens the lock in the chaperone, allowing usher targeting
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