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Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

Authors:	Dahai Luo Andrew Kohlway Adriana Vela Anna Marie Pyle

Institution:	1. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA;2. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA;3. Department of Chemistry, Yale University, New Haven, CT 06520, USA;4. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA

Abstract:	Download : Download high-res image (685KB) Download : Download full-size image Highlights? Crystallographic structure of RIG-I with 5′ triphosphorylated RNA duplex and ADP ? Solution biophysical analysis of ATP-dependent RIG-I conformational change ? The structural basis for ATP-stimulated RIG-I activation

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