红细胞分布宽度、中性粒细胞与淋巴细胞比值与晚期非小细胞肺癌患者临床病理特征及预后的关系研究

目的:探讨红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比值(NLR)与晚期非小细胞肺癌(NSCLC)患者临床病理特征及预后的关系.方法:选择2017年5月至2019年5月我院收治的106例确诊为晚期NSCLC患者(NSCLC组)和门诊接诊的102例体检正常者(对照组)作为研究对象.检测RDW、NLR,分析RDW、NL...

Relationship Research between Red Blood Cell Distribution Width, Neutrophils to Lymphocytes Ratio and Clinicopathological Characteristics and Prognosis of Advanced Non-small Cell Lung Cancer Patients

Objective:To investigate the relationship between red blood cell distribution width(RDW),Neutrophils to lymphocytes ratio(NLR)and clinicopathological characteristics and prognosis of advanced non-small cell lung cancer(NSCLC)patients.Methods:From May 2017 to May 2019,106 patients with advanced NSCLC(NSCLC group)in our hospital and 102 patients who were normal in physical examination(control group)were selected as the research object.Detection of RDW and NLR was performed,the relationship between RDW,NLR and clinicopathological characteristics and prognosis of NSCLC patients were analyzed.Results:RDW,NLR in the NSCLC group were higher than those in the control group(P<0.05),RDW in age≥60 years and lymph node metastasis with NSCLC patients were higher than those of age<60 years and no lymph node metastasis with NSCLC patients(P<0.05),NLR in TNM stagingⅣstage,lymph node metastasis with NSCLC patients were higher than those in TNM stagingⅢstage,no lymph node metastasis with patients(P<0.05).Kaplan-Meier survival curve analysis showed that the surose in the low RDW group and the low NLR group(P<0.05).Univariate COX regression analysis showed that the differentiation degree,TNM stage,lymphatic metastasis,RDW and NLR were correlated with the prognosis of NSCLC patients(P<0.05),while multivariate COX regression analysis showed that lymphatic metastasis,RDW and NLR were correlated with the prognosis of NSCLC patients(P<0.05).Conclusion:RDW and NLR of advanced NSCLC patients are higher,RDW is related to age and lymph node metastasis,NLR is related to TNM stage and lymph node metastasis.High levels of RDW and NLR predict poor prognosis of NSCLC,which can be used as auxiliary indicators for prognosis assessment.