髓腔内固定联合低强度脉冲超声对兔股骨中段骨折愈合作用研究

摘要 目的：针对髓腔内固定联合低强度脉冲超声对兔股骨中段骨折愈合作用进行研究。方法：选择成年兔股骨中段骨折40只，作为本次的研究对象，将其平均分为对照组和观察组。所有兔子，在手术前禁水、禁食，对其右后肢进行备皮，称重、麻醉，对照组实施髓腔内固定治疗，观察组实施髓腔内固定联合低强度脉冲超声治疗。治疗后1、2、3、4周对兔子的骨折部位进行影像学检查确定兔子的骨折线模糊情况，并在各周采集样品进行组织学检查。治疗4周后对骨折愈合情况进行检查。结果：观察组愈合程度I级、II级、II级比例均低于对照组相应比例，差异具有统计学意义（P＜0.05），观察组IV级、V级比例分别为35.0 %、55.0 %，均高于对照组的5.0 %、5.0 %，差异具有统计学意义（P＜0.05）；观察组兔子的在1 w、2 w、3 w、4 w骨折线模糊程度评分高于对照组相应时间评分，差异具有统计学意义（P＜0.05）。结论：在兔股骨中断骨折治疗中，实施髓腔内固定联合低强度脉冲超声，可以提高骨折的愈合速度，加速骨折修复，整体治疗效果显著，可以在临床上进行推广实施。

Effect of Intramedullary Fixation Combined with Low Intensity Pulsed Ultrasound on the Healing of Middle Femur Fracture in Rabbits

ABSTRACT Objective: To study the effect of intramedullary fixation combined with low intensity pulsed ultrasound on the healing of middle femoral fracture in rabbits. Methods: 40 adult rabbits with femoral fracture were divided into control group and observation group. All rabbits should be banned from water and food before the operation, and their right hind limbs were prepared, weighed and anesthetized. The control group was treated with intramedullary fixation, and the observation group was treated with intramedullary fixation combined with low intensity pulsed ultrasound. 1, 2, 3, and 4 weeks after treatment, the rabbit''s fracture site was examined by imaging to determine the blurring of the rabbit''s fracture line, and samples were collected for histological examination every week. Check fracture healing after 4 weeks of treatment. Results: The proportion of healing degree of grade I, II and II in the observation group was lower than that in the control group, and the difference was statistically significant(P<0.05). The proportion of grade IV and grade V in the observation group was 35.0 % and 55.0 % respectively, which were higher than 5.0 % and 5.0 % of the control group, and the difference was statistically significant(P<0.05); the fuzzy degree score of fracture line in the observation group at 1 week, 2 weeks, 3 weeks and 4 weeks was higher than that of the control group The difference was statistically significant(P<0.05). Conclusion: In the treatment of fracture in rabbits, the speed of fracture healing can be significantly improved by the implementation of ultrasound in the treatment of femoral fracture.