丁苯酞联合低剂量阿替普酶治疗急性脑梗死的疗效及对患者神经内分泌因子的影响

目的:探讨丁苯酞联合低剂量阿替普酶治疗急性脑梗死的疗效及对患者神经内分泌因子的影响。方法:按照随机数表法将105例患者分为对照组(n=52)和研究组(n=53)。对照组患者采用低剂量阿替普酶治疗,研究组患者在对照组基础上加用丁苯酞治疗。评价并比较两组临床疗效,比较两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分和血清S-100蛋白(S100B)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)水平,比较两组治疗14 d内的颅内出血发生率和病死率。结果:研究组的临床总有效率为94.34%(50/53),明显高于对照组的76.92%(40/52),且差异具有统计学意义(x2=6.502,P=0.011)。与治疗前相比,两组治疗后NIHSS评分均明显降低,且研究组治疗后的NIHSS评分明显低于对照组,差异有统计学意义(P<0.05)。与治疗前相比,两组治疗后血清S100B、NSE及MBP水平均明显降低(P<0.05),且研究组治疗后血清S100B、NSE及MBP水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗14 d内,研究组的颅内出血发生率和死亡率均明显低于对照组,差异有统计学意义(P<0.05)。结论:丁苯酞联合低剂量阿替普酶治疗急性脑梗死的疗效显著,能够明显改善神经功能,降低神经内分泌因子水平,且安全性较好。

Clinical Efficacy and Effect of Butylphthalide Combined with Low-dose Alteplase on Neuroendocrine Factors of Patients with Acute Cerebral Infarction

ABSTRACT Objective: To investigate the clinical efficacy and effect of butylphthalide combined with low-dose alteplase on neuroendocrine factors of patients with acute cerebral infarction. Methods: According to the random table method, 105 cases of patients with acute cerebral infarction were divided into the control group (n=52) and the research group (n=53). The patients in the control group were treated with low-dose alteplase, while the patients in the research group were treated with butylphthalide on the basis of the control group. The clinical efficacy of the two groups were evaluated and compared. The national institutes of health stroke scale (NIHSS) scores, serum S-100 protein (S100B), neuron-specific enolase (NSE), myelin basic protein (MBP) levels of two groups of patients before and after treatment were compared. The intracranial hemorrhage rates and mortality of the two groups during 14 days of treatment were compared. Results: The clinical efficacy rate of the research group was 94.34% (50/53), which was significantly higher than 76.92% (40/52) of the control group, and the difference was statistically significant (x²=6.502, P=0.011). Compared with before treatment, the NIHSS scores of the two groups after treatment were significantly lower, and the NIHSS scores of the research group after treatment was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Compared with before treatment, the levels of serum S100B, NSE and MBP in the two groups after treatment were significantly lower (P<0.05), and the levels of serum S100B, NSE and MBP in the research group after treatment were significantly lower than those in the control group, the difference was statistically significant (P<0.05). During 14 days of treatment, the intracranial hemorrhage rates and mortality of the research group were significantly lower than those of the control group, the difference was statistically significant (P<0.05). Conclusion: The clinical curative effect of butylphthalide combined with low-dose alteplase in the treatment of patients with acute cerebral infarction is significantly, which can significantly improve the neurological function, reduce the levels of the neuroendocrine factors, and it has good safty.