精氨酸及其代谢产物对缺血性脑卒中的作用

摘要：缺血性脑卒中是成年人群致残、致死的重要原因之一，有效治疗手段和药物的匮乏是脑卒中致残的主要原因。精氨酸既是一种营养物质，又具有多种独特的生理与药理作用，在早产儿和严重应激状态下精氨酸在维持正氮平衡与正常生理功能方面发挥重要作用，常将精氨酸称为条件必需氨基酸。精氨酸是生物体合成多胺的前体物质，同时精氨酸代谢也产生高活性自由基一氧化氮。精氨酸代谢及其代谢产物的改变可对脑卒中产生多种影响，如线粒体功能破坏、钙离子通道紊乱、血脑屏障损伤等。本文综述了精氨酸及其代谢产物在缺血性脑卒中病理过程中的作用。深入的研究和探讨其损伤和保护的双重作用机制将为缺血性脑卒中的防御和治疗提供新的策略。

Effects of Arginine and Its Metabolites in Cerebral Ischemia

ABSTRACT: Cerebral ischemia is one of the important causes of disability and death among adults. The lack of effective treatment and drugs are the predominant cause of disability in Cerebral ischemia. L-arginine is not only a nutrient, but also has many unique physiological and pharmacological effects. It is an essential amino acid in preterm infants and under severe stress. It can maintain nitrogen balance and normal physiological function. Arginine is the precursor of polyamine synthesis. Arginine metabolism also produces highly reactive nitric oxide (NO). The changes of arginine metabolism and its metabolites have a variety effects in Cerebral ischemia, such as mitochondrial damage, calcium imbalance, blood brain barrier damage, etc. This review summarized the role of arginine and its metabolites in the pathological process of Cerebral ischemia. Further research and discussion of its dual functions of injury and protection will provide a new strategy for the prevention and treatment of Cerebral ischemia.