中重度支气管哮喘急性发作期患儿Fe NO表达水平与肺功能的相关性研究

摘要 目的：探究中重度支气管哮喘急性发作期患儿呼出气一氧化氮（Fe NO）表达水平与肺功能的相关性。方法：选择2016年3月-2019年3月来我院就诊的中重度支气管哮喘急性发作期患儿69例为观察组，其中，中度支气管哮喘急性发作期患儿58例，重度支气管哮喘急性发作期患儿11例；另选取同期来我院体检的69例正常健康儿童作为对照组，对比观察组中中度、重度支气管哮喘急性发作期患儿Fe NO表达水平、用力肺活量（forced vital capacity，FVC）、最大呼气流量占预计值百分比（Maximum expiratory flow as a percentage of expected value，PEF%）、第一秒用力呼气容积占预计值的百分比（Forced expiratory volume as a percentage of expected value in the first second，FEV1%）与对照组健康儿童的差异，并对观察组患儿Fe NO表达水平与肺功能的相关性进行分析。结果：观察组患儿的Fe NO表达水平均高于对照组，且重度组患儿的Fe NO表达水平明显高于中度组（P＜0.05）；观察组患儿的PEF%、FEV₁%、FVC水平均高于对照组，且重度组患儿的PEF%、FEV₁%、FVC水平均高于中度组（P＜0.05）；观察组患儿Fe NO表达水平与FVC、PEF%、FEV₁%指标均呈负相关关系（r=-0.503、-0.551、-0.532，P均＜0.05）。结论：中重度支气管哮喘急性发作期患儿Fe NO表达水平与肺功能成负相关，可通过监测 Fe NO 水平间接判断炎症程度。

Correlation between Fe NO Expression Level and Pulmonary Function in Children with Moderate to Severe Bronchial Asthma

ABSTRACT Objective: To investigate the correlation between the expression level of exhaled nitric oxide (Fe NO) and lung function in children with acute bronchial asthma. Methods: 69 children with moderate to severe bronchial asthma who were admitted to our hospital from March 2016 to March 2019 were selected as the observation group. 58 children with moderate bronchial asthma and 11 patients with severe bronchial asthma during acute attack. In addition, 69 normal healthy children who were admitted to our hospital during the same period were selected as the control group. The expressions of Fe NO, forced vital capacity (FVC), maximum expiratory flow rate as a percentage of predicted value (PEF%), forced expiratory volume in the first second as a percentage of predicted value (FEV₁%) in children with moderate and severe bronchial asthma in the acute observation group were compared with healthy children in the control group. The correlation between Fe NO expression level and lung function in the observation group was analyzed. Results: The expression level of Fe NO in the observation group was higher than that in the control group, and the expression level of Fe NO in the severe group was higher than that in the moderate group. The difference was statistically significant (P<0.05). The PEF%, FEV₁%, and FVC levels in the observation group were higher than those in the control group, and the PEF%, FEV1%, and FVC levels in the severe group were higher than those in the moderate group (P<0.05). The expression of Fe NO in the observation group was negatively correlated with FVC, PEF% and FEV₁%(r=-0.503, -0.551, -0.532, P<0.05). Conclusion: The expression of Fe NO in children with moderate to severe bronchial asthma is negatively correlated with lung function. The degree of inflammation can be judged indirectly by monitoring the level of Fe NO.