枸橼酸咖啡因联合磷酸肌酸钠治疗新生儿呼吸窘迫综合征的疗效观察

目的:枸橼酸咖啡因联合磷酸肌酸钠治疗新生儿呼吸窘迫综合征的疗效,观察其对肺功能的影响.方法:选取我院新生儿科2016年6月至2019年6月收治的112例新生儿呼吸窘迫综合征的患儿作为研究对象,随机分为对照组和观察组(n=56).对照组患儿采取枸橼酸咖啡因联合呼吸机辅助呼吸治疗,观察组患儿在对照组基础上再联合磷酸肌酸钠治...

The Curative Effect Observation of the Citrate Caffeine Combined with the Creatine Phosphate Sodium for the Treatment of Neonatal Respiratory Distress Syndrome

ABSTRACT Objective: To explore the curative effect observation of the citrate caffeine combined with the creatine phosphate sodium for the treatment of neonatal respiratory distress syndrome, and analyze its influence on the on pulmonary function. Methods: 112 cases of neonatal respiratory distress syndrome of children in our hospital were selected as the research object from June 2016 to June 2019, and were randomly divided into control group and observation group (n=56). Children in the control group were given the caffeine citrate with breathing machine auxiliary breath therapy, and patients of the observation group were treated with sodium phosphocreatine on the basis of the control group. The clinical curative effect, blood gas analysis index, pulmonary function and the changes of myocardial enzymes were compared in two groups. At the same time, the adverse complications occurrence of bronchial pulmonary dysplasia (BPD) was also observed. Results: After 24 h and 48 h treatment, PaO₂ in two groups and considerably increased as well as PaO₂/FiO₂, but PaCO₂ was significantly decreased (P<0.05). PaO₂ and PaO₂/FiO₂ in the observation group were higher than that of control group, the difference was statistically significant (P<0.05). After 24 h treatment, FEV₁ and FEV₁/FVC of two groups were obviously higher, and FEV₁/FVC of the observation group was significantly higher than control group(P<0.05). After 48 h treatment, FEV₁ and FEV₁/FVC were further improved, which was significantly better than control group(P<0.05). After treatment, CK-MB and LDH levels in two groups were gradually declined, the LDH and CK-MB in the observation group were obviously lower than that of control group(P<0.05). The total effective rate of the observation group was 91.07%, significantly higher than control group 82.14%. The incidence of adverse reactions to BPD was lower than the control group with the statistically significant difference(P<0.05). Conclusion: The treatment of caffeine citrate combined with creatine sodium phosphocreatine for NRDS was effect, which can effectively improve the pulmonary function in children by reducing myocardial injury, and reduce the incidence of cardiopulmonary complications adverse reactions, help prognosis. It was worthy of clinical popularization and application.