婴幼儿重症肺炎潮气呼吸肺功能、D-二聚体水平的变化及盐酸氨溴索的干预效果研究

摘要 目的：探讨婴幼儿重症肺炎潮气呼吸肺功能、D-二聚体水平的变化及盐酸氨溴索的干预效果研究。方法：2016年1月至2019年12月期间我院收治的重症肺炎婴幼儿122例作为肺炎组，另选取同期来我院行健康体检的婴幼儿100例作为对照组，肺炎组患儿采用随机数字表法分为A组（n=61，常规治疗）和B组（n=61，常规治疗基础上联合盐酸氨溴索治疗），对比对照组、肺炎组潮气呼吸肺功能、D-二聚体水平，对比A组、B组两组的疗效、潮气呼吸肺功能、D-二聚体、症状缓解时间及不良反应。结果：肺炎组呼吸频率（RR）、D-二聚体水平高于对照组，潮气量（VT）、达峰时间（TPTEF）、吸气时间（TI）、呼气时间（TE）短于对照组（P<0.05）。B组治疗1周后的总有效率高于对照组（P<0.05）。两组治疗1周后RR、D-二聚体水平均下降，且B组低于A组（P<0.05），两组治疗1周后VT、TPTEF、TI、TE均升高，且B组高于A组（P<0.05）。B组退热时间、咳嗽缓解时间、气促缓解时间、啰音消失时间均短于A组（P<0.05）。A组、B组两组患儿不良反应总发生率对比未见差异（P>0.05）。结论：D-二聚体以及潮气呼吸肺功能检测可作为婴幼儿重症肺炎治疗效果、病情程度评价的重要指标，经盐酸氨溴索干预后患儿D-二聚体及潮气呼吸肺功能均可得到显著改善，临床症状可有效缓解，疗效肯定，且不增加不良反应发生。

Changes of Tidal Breathing Pulmonary Function and D-dimer Level in Infants with Severe Pneumonia and Study of the Intervention Effect of Ambroxol Hydrochloride

ABSTRACT Objective: To investigate the changes of tidal breathing pulmonary function and D-dimer level in infants with severe pneumonia and the study of intervention effect of ambroxol hydrochloride. Methods: 122 infants with severe pneumonia admitted to our hospital from January 2016 to December 2019 were selected as the pneumonia group, and 100 infants who came to our hospital for health examination at the same period were selected as the control group. The pneumonia group was randomly divided into group A (n=61, conventional treatment) and group B(n=61, combined with ambroxol hydrochloride on the basis of conventional treatment) by random number table method, and the tidal breathing, pulmonary function and D-dimer level of control group and pneumonia group was compared. The curative effect, tidal breathing pulmonary function, D-dimer, symptom remission time and adverse reactions of group A and group B were compared. Results: The respiratory rate (RR) and D-dimer levels in the pneumonia group were higher than those in the control group, while the tidal volume (VT), time to peak (TPTEF), inspiratory time (TI) and expiratory time (TE) in the pneumonia group were lower than those in the control group(P<0.05). The total effective rate in group B was higher than that in control group at 1 week after treatment(P<0.05). 1 week after treatment, RR and D-dimer in both groups were decreased, and group B was lower than the control group(P<0.05). 1 week after treatment, VT, TPTEF, TI, TE in both groups were increased, and group B was higher than group A (P<0.05). The antipyretic time, cough relief time, shortness of breath remission time and rales disappearance time in group B were shorter than those in group A(P<0.05). There was no difference in the total incidence of adverse reactions between group A and group B (P>0.05). Conclusion: The detection of D-dimer and tidal breathing pulmonary function can be used as an important index to evaluate the severity and treatment effect of severe pneumonia in infants. After ambroxol hydrochloride intervention, tidal breathing pulmonary function and D-dimer can be significantly improved, clinical symptoms can be effectively alleviated, the curative effect is affirmative, and there is no increase in adverse reactions.