蛋白质组氨酸磷酸化研究进展

摘要：蛋白质磷酸化是一种可逆的翻译后修饰，这种翻译后修饰可以改变蛋白质的构象，进而使蛋白质活化或者失活。组氨酸磷酸化在细胞信号传导过程中发挥着重要作用，且组氨酸磷酸化与人类某些疾病密切相关，然而，由于组氨酸磷酸化含有P-N键，具备不稳定性，有关于组氨酸磷酸化的报道远远少于其它磷酸化的报道。本综述系统的总结了组氨酸磷酸化在生物学过程中的作用，以及近些年取得的重要研究进展，以期对深入研究组氨酸磷酸化提供理论参考。

Review on Histidine Phosphorylation in Protein

ABSTRACT: As a reversible posttranslational modification, phosphorylation can modulate the protein''s activity through altering its conformation. Histidine phosphorylation plays a key role in signal transduction and is frequently involved in various human diseases. Due to the lability of the phosphoramidate (P-N) bond of phosphohistidine, histidine phosphorylation is still difficult to detect and has only been reported by a relative handful of studies, which is much less than other phosphorylation modification. In this article, we review the advance of studies on the histidine phosphorylation in recent years and summary its biological functions, which can provide theoretical support for further research.