人滋养细胞表面抗原（Trop-2）在病变子宫内膜中表达的研究

摘要 目的：探讨人滋养细胞表面抗原（trophoblast cell-surface antigens2，Trop-2）在病变子宫内膜中的表达及其临床相关性。方法：采用免疫组化法检测100例正常子宫内膜或病变子宫内膜组织中Trop-2蛋白的表达，其中单纯增生子宫内膜患者26例，复杂或不典型增生子宫内膜患者34例，子宫内膜腺癌患者20例，对照组为20例增生期子宫内膜患者。结果：免疫组织化学法研究结果显示，Trop-2蛋白在正常增生子宫内膜和单纯性增生子宫内膜中几乎不表达，在复杂或不典型增生子宫内膜组织中以及子宫内膜腺癌呈阳性表达。主要分布在细胞膜上，阳性率分别为35.29 %和65.00 %，经过对比子宫内膜癌组的阳性表达率显著高于复杂型或伴不典型增生子宫内膜组的阳性表达率（P<0.05），且复杂型或伴不典型增生子宫内膜组的阳性表达率显著高于单纯性增生子宫内膜组（P<0.05），其表达水平随内膜病变程度的加重而升高，呈正相关关系（P＜0.05）。结论：Trop-2蛋白在子宫内膜病变中的表达与其严重程度一致，可反映子宫内膜病变的发生发展，或可作为判断其严重程度的指标。

Expression and Significance of Trop-2 in Endometrial Lesions

ABSTRACT Objective: To investigate the expression and clinical significance of human trophoblast cell surface antigen (Trop-2) in endometrial lesions. Methods: Immunohistochemical method was used to detect the expression of Trop-2 in normal endometrium or diseased endometrium in 100 patients, including 26 cases of simple hyperplasia endometrium, 34 cases of complex or atypical hyperplasia of endometrium, 20 cases of endometrial adenocarcinoma, and 20 cases of proliferative phase endometrium in the control group. Results: The findings showed that Trop-2 was not expressed in proliferative phase endometrium group and simple hyperplasia endometrium group, but positively expressed in complex or atypical hyperplasia endometrium group and endometrial carcinoma group, mainly distributing on the cell membranes, the positive rates were 35.29 % and 65.00 %, respectively. After comparison, the positive expression rate of the endometrial cancer group was significantly higher than that of the complex type or with atypical hyperplasia endometrium group (P<0.05), and the positive expression rate of the complex type or with atypical hyperplasia endometrium group was significantly higher than that of the simple hyperplasia endometrium group (P<0.05). Its expression level increased with the severity of endometrial lesions, which is positively correlated (P<0.05). Conclusion: The expression of Trop-2 protein in endometrial lesions is consistent with the severity of endometrial lesions. Maybe it will be used as an indicator to judge the severity of endometrial lesions.