基于定量CT分析哈尔滨地区人群腹部脂肪面积与血脂、血糖的相关性

目的:通过定量CT检测哈尔滨地区人群腹部脂肪面积,并分析其与血脂、血糖水平的相关性。方法:选取于哈医大附属一院体检中心行肺部CT检查、20周岁以上的患者411例,年龄23~90岁,中位年龄58岁。分别进行体格检查和生化指标测定,根据体重指数(Body Mass Index,BMI)值将患者分为正常组、超重组及肥胖组,并使用定量CT(quantitative CT,QCT)脂肪测量软件定量测量患者L2~3水平层面腹部内脏脂肪面积(visceral fat area,VFA)和皮下脂肪面积(subcutaneous fat area,SFA)。将VFA和SFA数据分组,比较各组间VFA值、SFA值的差异,并进行相关性分析。结果:三组VFA值(P=0.000、0.000、0.033)及SFA值(P=0.000、0.000、0.000)比较均有显著性差异(P均<0.05),均为肥胖组>超重组>正常组。VFA值均与血脂、血糖有显著的相关性(VFA与TG的r值分别为0.466、0.15、0.318,P值分别为0、0.042、0.033;VFA与FBG的r值分别为0.357、0.171、0.417,P值分别为0、0.02、0.004)。绘制VFA诊断甘油三酯(TG)及空腹血糖(FBG)值异常的ROC曲线图,当VFA分别为166.035 cm2和172.65cm2时,对于诊断TG、FBG异常敏感度及特异度最高。结论:BMI正常组及非正常组人群腹部脂肪面积具有显著差异,且VFA的升高会增加高血脂、高血糖的患病风险。VFA对于评估TG、FBG值是否正常具有重要的应用价值。

A Study on the Relationship between Abdominal Fat Area, Blood Lipids and Qlucose in Harbin Population Based on Quantitative CT

Objective: To detect the area of abdominal fat in Harbin area by quantitative CT and analyze its correlation with the level of blood lipid and blood glucose. Methods: 411 patients over 20 years old, aged 23-90 years, with a median age of 58 years, were selected for lung CT examination in the First Affiliated Hospital of Harbin Medical University. According to the body mass index(BMI),the patients were divided into normal group, super recombination group and obesity group. The VFA and subcutaneous fat area were measured by quantitative CT(QCT) fat measurement software area,SFA.Group VFA and SFA data, compare the difference of VFA value and SFA value, and analyze the correlation. Results: There were significant differences in VFA(P=0.000, 0, 0.033) and SFA(P=0.000, 0, 0) between the three groups(P<0.05). VFA and TG had r value of 0.466, 0.15 and 0.318 respectively, P value of 0.042 and 0.033 respectively;VFA and FBG had r value of 0.357, 0.171 and 0.417 respectively, P value of 0.02 and 0.004 respectively. When VFA was 166.035 cm2 and 172.65 cm2 respectively, the sensitivity and specificity of VFA were the highest. Conclusion: There is a significant difference in abdominal fat area between normal and Abnormal BMI groups, and the increase of VFA will increase the risk of hyperlipidemia and hyperglycemia. VFA has important application value in evaluating TG and FBG.