Binding of von Willebrand factor and plasma proteins to the eggshell of Schistosoma mansoni |
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| Authors: | Saskia deWalick,Paul J. Hensbergen,Michiel L. Bexkens,Christina Grosserichter-Wagener,Cornelis H. Hokke,André M. Deelder,Philip G. de Groot,Aloysius G.M. Tielens,Jaap J. van Hellemond |
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| Affiliation: | 1. Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands;2. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands;3. Department of Parasitology, Center for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands;4. Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands |
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| Abstract: | Schistosoma mansoni eggs have to cross the endothelium and intestinal wall to leave the host and continue the life cycle. Mechanisms involved in this essential step are largely unknown. Here we describe direct binding to the S. mansoni eggshell of von Willebrand factor and other plasma proteins involved in haemostasis. Using deletion-mutants, we demonstrated that it is the A1 domain of von Willebrand factor that binds to the eggshell. Our results suggest that binding of plasma proteins to the eggshell promotes binding to the endothelium, initiating the passage of the egg through the blood-vessel wall to be excreted in the end. |
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| Keywords: | Schistosomiasis Eggshell von Willebrand factor Plasma proteins Haemostasis Schistosoma mansoni Egg excretion |
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